Results 221 to 230 of about 1,321,562 (288)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Change in Breast Cancer Screening Participation during COVID-19 Based on the 2019 and 2022 Comprehensive Survey of Living Conditions in Japan. [PDF]

JMA J
Kawamura C, Iwagami M, Komiyama J, Taniguchi Y, Sun Y, Masuda R, Sugiyama T, Bando H, Kihara T, Iso H, Tamiya N.   +10 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Diet, physical activity, and sleep in relation to postprandial glucose responses under free-living conditions: an intensive longitudinal observational study. [PDF]

Int J Behav Nutr Phys Act
Yao J, Brugger VK, Edney SM, Tai ES, Sim X, Müller-Riemenschneider F, van Dam RM.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Habitual water intake impacted the body composition of young male athletes in free-living conditions: a cross-sectional study. [PDF]

Front Sports Act Living
Zhang J, Zhang N, Li Y, He H, Song G, Chen J, Yan Y, Ma G.   +7 more
europepmc   +1 more source

Continuous Monitoring of Heart Rate Variability in Free-Living Conditions Using Wearable Sensors: Exploratory Observational Study. [PDF]

JMIR Form Res
Gaur P, Temple DS, Hegarty-Craver M, Boyce MD, Holt JR, Wenger MF, Preble EA, Eckhoff RP, McCombs MS, Davis-Wilson HC, Walls HJ, Dausch DE.   +11 more
europepmc   +1 more source

Childhood living conditions as predictors of self-rated health status in middle-aged and older adults: Evidence from a machine learning analysis in 27 high-income countries

Zong X, Silventoinen K, Martikainen P, Nelimarkka M.   +3 more
europepmc   +1 more source

Living Conditions Alter Ketogenic Diet-induced Metabolic Consequences in Mice through Modulating Gut Microbiota. [PDF]

Phenomics
Yang J, Li X, Dai C, Teng Y, Xie L, Tian H, Hong S.   +6 more
europepmc   +1 more source

The influence of modern living conditions on the human microbiome and potential therapeutic opportunities for allergy prevention. [PDF]

World Allergy Organ J
Zhang G, Le Souëf P.
europepmc   +1 more source