Results 211 to 220 of about 10,407,445 (289)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Development of Non-Invasive Continuous Glucose Prediction Models Using Multi-Modal Wearable Sensors in Free-Living Conditions. [PDF]

Sensors (Basel)
Karunarathna TS, Liang Z.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Living conditions of children [PDF]

, 2009
openaire   +1 more source

Madagascar rural observatory surveys, a longitudinal dataset on household living conditions 1995-2015. [PDF]

Sci Data
Andrianjafindrainibe VS, Andrianirina N, Bédécarrats F, Droy I, Dubois JL, de Montalembert J, Rabevohitra BN, Rafidimanana R, Rasolofo P, Ratovoarinony R, Ratsaramiarina LAO, Ravelonandro JD, Razanamavo V, Razafindrakoto M, Rivolala B, Roubaud F, Saint-Macary C.   +16 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The impact of biotechnology on the environment: a literature review of environmental applications and impacts of biotechnology

, 1987
European Foundation for the Improvement of Living and Working Conditions
core  

Impact of the improvement of living conditions on tuberculosis mortality in Brazil: an ecological study. [PDF]

Sao Paulo Med J
Natividade M, Pereira M, Stauber C, Miranda S, Teixeira MG, Souza RA, Anjos MSD, Barros R, Morato DG, Aragão E, Pereira SM, Costa MDCN.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Quantification of Differences in Sleep Measurement by a Wrist-Worn Consumer Wearable Compared to Research-Grade Accelerometry and Sleep Diaries of Female Adults in Free-Living Conditions. [PDF]

Nat Sci Sleep
Hu CR, Delaney C, Chavarro JE, Laden F, Librett R, Katuska L, Kaplan ER, Yi L, Rueschman M, Kossowsky J, Onnela JP, Coull BA, Redline S, James P, Hart JE.   +14 more
europepmc   +1 more source