Results 241 to 250 of about 142,808 (310)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Non-HLA Genetics and Application to Living Donor Candidates. [PDF]

open access: yesCurr Transplant Rep
Caliskan Y   +5 more
europepmc   +1 more source

Human leukocyte antigen-incompatible living donor kidney transplantation after desensitization: experience from a major transplant centre in Mexico. [PDF]

open access: yesTranspl Int
Reynoso de la Torre HL   +19 more
europepmc   +1 more source

A technical modification in cavo-portal hemi-transposition in adult living donor liver transplantation. [PDF]

open access: yesAnn Hepatobiliary Pancreat Surg
Makki K   +5 more
europepmc   +1 more source

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