Results 151 to 160 of about 858,253 (312)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Our shared environment 2020. Environmental programme for Uusimaa region

, 2007
There are some 1.5 million people living in the Uusimaa Region, and the population continues to grow rapidly. The Helsinki Metropolitan Area has the only large concentration of population in Finland.

core  

Older adults' active mobility choices and their specific preferences and needs for their living environment: an intersectional approach. [PDF]

BMC Public Health
Horstmann S, Baumgart S, Bolte G.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Breakwaters In A Living Environment

CoastLab 2024: Physical Modelling in Coastal Engineering and Science
Breakwaters protecting harbors and coastal areas are key to the economic and social development of many countries, but they are also infrastructures which may result in relevant environmental and social impacts. The construction of new breakwaters in developing countries, together with the dismantling, rehabilitation or repair of old breakwaters in ...
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Urban Living Environment and Myopia in Children.

JAMA Netw Open, 2023
Li X, Li L, Qin W, Cao Q, Mu X, Liu T, Li Z, Zhang W.   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Healthy living environment, healthy people

, 2017
In opdracht van de minister van Infrastructuur en Milieu (IenM) worden de Nationale Omgevingsagenda (NOA) en Nationale Omgevingsvisie (NOVI) ontwikkeld.
Staatsen BAM, van Alphen Th, Broek I van den, Kruize H, Houweling DA   +4 more
core  

Associations between the living environment and sleep through the mediation of the physical activity: a systematic review. [PDF]

BMC Public Health
Scouvemont M, Elsen C, Tannoia V, Schaff G, Adam S, Schmidt C, Beliy N, Bruyère O.   +7 more
europepmc   +1 more source