Results 161 to 170 of about 858,253 (312)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Editorial: The built environment and public health: New insights

Frontiers in Public Health, 2023
Linchuan Yang, Ruoyu Wang, Baojie He, Yu Ye, Yibin Ao   +4 more
doaj   +1 more source

Impact of Living Environment on Attachment Behaviour in Domestic Cats from Private Homes and Shelters. [PDF]

Animals (Basel)
Kappel I, Materne B, Gansloßer U.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Productivity Trends in Natural Resources Industries in Canada [PDF]

The objective of this report is to provide an overview of the evolution of productivity in the natural resources industries in Canada over the last 40 years.
Centre for the Study of Living Standards
core  

Perception of the Residential Living Environment: The Relationship Between Objective and Subjective Indicators of the Residential Living Environment and Health. [PDF]

Int J Environ Res Public Health
Gotink J, Gadeyne S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bayesian network analysis of cognitive impairment in empty-nest older adults: the role of living environment. [PDF]

Front Public Health
Zhang S, Tian Y, Feng N, Li J, Zhang T, Deng L, Fu J.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Household structures of elderly in the past: a case study of two Dutch communities in the periode 1920-1940

, 1990
The continuing aging of the population sparked off a public discussion on the extent of state care of elderly people. A historical evaluation of the Dutch system of family care is an essential part in the above discussion, especially regarding options ...
Bulder, Elles
core