Results 101 to 110 of about 656,579 (254)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Book Review: Guédelon - Building a French Castle the 13th Century Way
EXARC Journal, 2013 Guédelon: How to Build a Castle by Darques is by no means a DIY book or a guided tour on paper of the Guédelon site. Guédelon: a Castle in the Making by Martin and Renucci is subtitled The Guédelon Adventure and although it carries a lot of information ...
Roeland P Paardekooper
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
EXARC Journal, 2014 2012 OpenArch meeting at Foteviken (SE) In his 2007 book, Living History Museums: Undoing History through Performance, Scott Magelssen describes the various reactions to his main line of enquiry: is historical interpretation theatre?
Ashlee Beattie
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Obituary: Mats Geschwind, Founder of Storholmen Viking Village (20 May 1961 - 25 May 2014)
EXARC Journal, 2015 The Viking Village Storholmen is an archaeological open-air museum, beautifully situated near Lake Erken, ten kilometres north of the coastal town of Norrtälje, Roslagen, Sweden.
Eva IJsveld, Björn M Buttler Jakobsen
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
What Does Your Visitor Experience? Making the Most of Live Interpretation in a Unique Setting
EXARC Journal, 2015 Archaeological Open-Air Museums (AOAM) offer a unique setting in which live interpretation can make history come truly alive. For many, or perhaps all, AOAM history is the product being sold to the public.
Marc van Hasselt
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source