Results 171 to 180 of about 3,377,831 (304)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Workshop on Exercise Prescription for Long-Duration Space Flight [PDF]

The National Aeronautics and Space Administration has a dedicated history of ensuring human safety and productivity in flight. Working and living in space long term represents the challenge of the future.
Harris, Bernard A., Jr., Stewart, Donald F.   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Determinants of precancerous cervical lesion among HIV positive women on ART in Awi zone public health facilities, Northwest Ethiopia, 2024. [PDF]

Sci Rep
Endalew A, Kassahun M, Habtegiorgis SD, Tsega TD, Kindie S, Wolie AA, Eshetu DM, Tadele S, Abebe N.   +8 more
europepmc   +1 more source

European Union after 50 years of existence [PDF]

The unification process has been the central point of the european political and economic history in the second half of the last century. The advances made seem today impressing and impossible to imagine only a few years ago: peace and stability have ...
Mihai Berinde
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Determinants of tetanus-unprotected births in Tanzania: a multilevel analysis using the 2022 Tanzania Demographic and Health Survey data. [PDF]

Matern Health Neonatol Perinatol
Negussie YM, Seifu BL, Asnake AA, Fente BM, Asebe HA, Melkam M, Bezie MM, Tsega SS, Asmare ZA, Gebrehana AK.   +9 more
europepmc   +1 more source

Relationship Issues of Azerbaijani and Georgian Intellectuals [PDF]

In the article, the people's interrelationship problems of the present two neighbor countries - Georgia and Azerbaijan in the period of the newest history is discussed for the first time.
Nata Bicadze
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Associations of living alone and loneliness with neuropsychiatric symptoms in individuals with mild cognitive impairment: A retrospective cross-sectional study. [PDF]

PCN Rep
Takeda K, Kanemoto H, Suehiro T, Satake Y, Taomoto D, Katakami S, Yoshiyama K, Ikeda M.   +7 more
europepmc   +1 more source