Results 171 to 180 of about 656,579 (254)

Knowledge of HPV and HPV vaccine and its association with vaccination willingness among female undergraduates: A comparative cross-sectional study between healthcare and non-healthcare majors in Chengdu, China. [PDF]

PLoS One
Zhao M, Lei J, Feng Q, Lai S, Liang Q, Xie M.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Characteristics of Adolescents and Young Adults Visiting an Emergency Department Due to Self-Harm or Suicide Attempts: Risk Factors for Severe Medical Outcome and Short-Term Revisits. [PDF]

J Korean Med Sci
Park K, Kim TH, Song KJ, Shin J, Jung JH, Lee HJ, Kim YH, Lee SGW.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Prevalence, related factors, and outcomes of fear of childbirth in pregnant women visiting health centers in Tabriz, Iran: a prospective study. [PDF]

Sci Rep
Alizadeh-Dibazari Z, Abbasalizadeh F, Mohammad-Alizadeh-Charandabi S, Jahanfar S, Mirghafourvand M.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Incidence and risk factors of <i>C. trachomatis</i>, <i>N. gonorrhoeae</i> and syphilis among a cohort of urban Canadian gay, bisexual and other men who have sex with men, 2017-2023: informing the potential impact of doxycycline prophylaxis. [PDF]

BMJ Open
Lambert G, Fourmigue A, Dvorakova M, Moodie EEM, Moore D, Lachowsky NJ, Grace D, Hart TA, Tan DHS, Jollimore J, Labbé AC, Fortin C, Maheu-Giroux M, Hull M, Grennan T, Brunelle-Newman S, Zhang T, Lal A, Gormezano A, Cox J.   +19 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Latent Class Analysis of Suicide Methods and Associated Background Characteristics: A Forensic Epidemiological Study in Osaka. [PDF]

JMA J
Murakami R, Morioka D, Fukui K, Hiraide A, Kuroki H.   +4 more
europepmc   +1 more source