Results 61 to 70 of about 656,579 (254)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Book Review: Mittelsteinzeit, ein Leben im Paradies? by Werner Pfeifer

open access: yesEXARC Journal, 2020
Considering actual studies about the analysis of ancient DNA is an important question, if only the lifestyle or the population, too, changed when hunter-gatherers became farmers and stockbreeders.
Michael Müllers
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Book Review: Performing Heritage: Research, Practice and Innovation in Museum Theatre and Live Interpretation by Anthony Jackson and Jenny Kidd (eds)

open access: yesEXARC Journal, 2014
This useful text brings together recent thinking about museum theatre and the performance of heritage, offering a range of international case studies to its readers as evidence of the discipline’s usefulness in interpreting the past for visitors ...
Kirsty Sullivan
doaj  

The interpretation of historical and cultural heritage in modern museum complexes. Architecture Issues / Интерпретация историко-культурного наследия в современных музейных комплексах. Вопросы архитектуры [PDF]

open access: yesСоциология города, 2018
The article is devoted to the problems of actualization of the historical and cultural heritage and the new approaches to its exposure in modern museum complexes.
Antyufeeva O. A. / Антюфеева О. А.
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Book Review: Geschichtstheater. Formen der "Living History" by Wolfgang Hochbruck

open access: yesEXARC Journal, 2016
The dramatisation of history is ubiquitous in our postmodern everyday life: historical novels (as well as their TV adaptations, netting huge audience figures), documentaries, and stylistic references and citations evoking the past in fashion and ...
Ibrahim Karabed
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

The Attack on the Tooth Worm

open access: yesEXARC Journal, 2016
A unique approach to heritage interpretation; by analysing and reconstructing medieval dental treatments through research and re-enactment. It is the year 1350 in Gravendam, the medieval town of Archaeological Open-air Museum (AOAM) Archeon in the ...
Wiel van der Mark
doaj  

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