Results 91 to 100 of about 913,122 (305)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Bottom-up radio: creating a new media format using living lab research [PDF]

open access: yes, 2013
This study resulted in the creation of a new media format for urban youth, adopting a living lab-approach, as current studies have shown that this group is currently not reached with the contemporary media offer.
All, Anissa   +2 more
core  

Microswimmers in Patterned Environments

open access: yes, 2011
We demonstrate with experiments and simulations how microscopic self-propelled particles navigate through environments presenting complex spatial features, which mimic the conditions inside cells, living organisms and future lab-on-a-chip devices.
Bechinger, Clemens   +4 more
core   +2 more sources

Comparison of Health and Wellbeing Living Lab Business Models : Preliminary result based on Business Model Canvas Evaluation [PDF]

open access: yes, 2018
The most popular thematic focus area among ENoLL members is the health and wellbeing, which covers nearly a half of all the certified Living Labs. However, the studies evaluating Living Lab (LL) business models in general and especially those focusing on
Julin, Mikko, Santonen, Teemu
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Innovation from user experience in Living Labs: revisiting the ‘innovation factory’-concept with a panel-based and user-centered approach [PDF]

open access: yes, 2012
This paper focuses on the problem of facilitating sustainable innovation practices with a user-centered approach. We do so by revisiting the knowledge-brokering cycle and Hargadon and Sutton’s ideas on building an ‘innovation factory’ within the light of
Ballon, Pieter   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

CLEF NewsREEL 2016: Comparing Multi-Dimensional Offline and Online Evaluation of News Recommender Systems [PDF]

open access: yes, 2016
Running in its third year at CLEF, NewsREEL challenged participants to develop news recommendation algorithms and have them benchmarked in an online (Task 1) and offline setting (Task 2), respectively.
Brodt, Torben   +7 more
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Agro Living Lab

open access: yesSuomen Maataloustieteellisen Seuran Tiedote, 2010
Käytettävyys on tuotteen ominaisuus, joka määrittelee, kuinka hyvin tuote vastaa tavoiteltua käyttötarkoitustaan ja kuinka hyvin käyttäjä pystyy hyödyntämään tuotteen toimintoja. Hyvä käytettävyys havaitaan mm. tuotteen käytön helppoutena, nopeutena ja miellyttävyytenä.
Esala, Jussi, Kankaanpää, Sanna
openaire   +2 more sources

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