Results 81 to 90 of about 912,341 (301)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Living Labs as Tools for Open Innovation [PDF]

This paper presents a Living Lab in Stockholm as a focal point for discussing how the Living Lab concept can be extended and used for engaging in multiorganizational open innovation.
Håkan OZAN, Mats EDENIUS, Niklas Z. KVISELIUS, Per ANDERSSON   +3 more
core  

Medical diagnostics using designed molecules with sense and logic [PDF]

, 2013
Luminescent molecules responsive to cations, anions and even small molecules can be designed with the appropriate selectivity and sensitivity for monitoring physiological and pathological levels of analytes.
Cardona, Mario, Farrugia, Kristina, Magri, David C.   +2 more
core   +1 more source

Nursing theories as guidance for autonomy support in activities of daily living: a scoping review

BMC Nursing
Background Supporting others with self-care activities lies at the core of nursing practices. While supporting autonomy within essential care is important, there remains a lack of knowledge on what autonomy comprises and how nurses can demonstrate ...
Melissa Botana Gronek, Michel Bleijlevens, Stan Vluggen, Esmee Moonen, Aileen Van Dijk, Petra Erkens, Sandra Zwakhalen, Jan Hamers, Judith Meijers   +8 more
doaj   +1 more source

A survey of nutritional education within the Holiday Activities and Food programme across England

Frontiers in Public Health
BackgroundNutritional education is a mandatory component of the Holiday Activities and Food (HAF) programme in England, yet there is a paucity of literature exploring how this component is delivered.
Emily K. Round, Paul B. Stretesky, Margaret Anne Defeyter   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Predicting food insecurity among UK university students during the COVID-19 pandemic

Public Health Nutrition
Objective: The present study investigated potential predictors of food insecurity among UK university students during the COVID-19 pandemic. Design: Close-ended questionnaire administered to a cross-sectional sample of UK university students. Setting:
Emily K Round, Sarah Weatherston, Paul B Stretesky, Margaret Anne Defeyter   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Field observations in a living lab context: constructing a framework for the observers' role based on a comparative case study analysis [PDF]

, 2014
When developing innovations, particularly media innovations, there is a growing interest in user involvement for innovation development processes (Bogers, Afuah, & Bastian, 2010).
Baccarne, Bastiaan, Georges, Annabel, Logghe, Sara, Schuurman, Dimitri   +3 more
core   +1 more source