Results 91 to 100 of about 2,732,997 (292)

Applying a Living Lab methodology to support innovation in education at a university in South Africa

The Journal for Transdisciplinary Research in Southern Africa, 2015
The Living Lab paradigm creates open and inter-disciplinary environments where participants can interrogate challenges and co-create solutions. A successful Living Lab context incorporates a clear focus/vision, strong leadership, self-sustainability, a ...
Ronel Callaghan, Marlien Herselman
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Living labs as catalysts for integrated primary care: insights from a comprehensive community survey and co-creative design of community-based prevention and primary care

BMC Primary Care
Background Societal changes in terms of healthcare needs call for adaptations in the organisation of primary care. Policies and services need to be aligned to communities’ needs and a shift towards inclusive integrated care is warranted.
Nele A. J. De Witte, Kim Helsen, Sascha Vermeylen, Hilde Vandenhoudt, Ingrid Adriaensen, Lieven Janssens, Vicky Van der Auwera   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Digital Storytelling for Community Participation: The Storyelling Social Living Lab [PDF]

, 2018
This chapter outlines a social living lab initiative led by the Fostering Digital Participation (FDP) project that aimed to encourage digital participation among a particular group of community members in the regional centre of Toowoomba (Queensland ...
Cherie Allan, Allan, Cherie, Mallan, Kerry M., Michael Dezuanni, Kerry Mallan, Dezuanni, Michael L.   +5 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Into the wild: how living labs are being used to connect people with dementia to nature—a mini review

Frontiers in Dementia
With the global rise in dementia diagnoses and no available cure, there is an urgent need for accessible, enjoyable, and holistic interventions that support people experiencing dementia to live well. Nature engagement has been shown to offer wide-ranging
Cassandra J. Thomson, Sharon Stoddart, Hoang Nguyen, Shuzhen Joanna Sun, Alice Rota-Bartelink, Pauline Marsh   +5 more
doaj   +1 more source

El cubo de armonización HSB Living Lab

Informes de la Construccion, 2017
Los Living Labs están emergiendo como instrumentos de innovación en actividades centradas en el usuario. Debido al variado rango de enfoques, constelaciones, prácticas, resultados y longevidad, igualmente variadas metodologías se han usado para describir
A. Sasic Kalagasidis, S. Hagy, Ch. Marx
doaj   +1 more source