Results 61 to 70 of about 912,341 (301)

Getting personal: exploring the usage of persona in order to optimize the involvement of a living lab panel [PDF]

, 2015
iMinds Living Labs started with living lab research in 2009. Living lab research involves gathering user feedback on innovations implemented in a real-life context (Eriksson et al., 2005).
Logghe, Sara
core   +1 more source

The relation between resident-related factors and care problems in nursing homes: a multi-level analysis

BMC Health Services Research
Background Care problems such as decubitus and fall incidents are prevalent in nursing homes. Yet, research regarding explanatory factors on these care problems is scarce.
Suleyman Bouchmal, Yvonne M. J. Goërtz, Coen Hacking, Bjorn Winkens, Sil Aarts   +4 more
doaj   +1 more source

Applying a Living Lab methodology to support innovation in education at a university in South Africa

The Journal for Transdisciplinary Research in Southern Africa, 2015
The Living Lab paradigm creates open and inter-disciplinary environments where participants can interrogate challenges and co-create solutions. A successful Living Lab context incorporates a clear focus/vision, strong leadership, self-sustainability, a ...
Ronel Callaghan, Marlien Herselman
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Innovation from user experience in Living Labs: revisiting the ‘innovation factory’-concept with a panel-based and user-centered approach [PDF]

, 2012
This paper focuses on the problem of facilitating sustainable innovation practices with a user-centered approach. We do so by revisiting the knowledge-brokering cycle and Hargadon and Sutton’s ideas on building an ‘innovation factory’ within the light of
Ballon, Pieter, De Marez, Lieven, Lievens, Bram, Schuurman, Dimitri   +3 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Innovation is created by humans, not by systems: an exploration of user involvement in living labs: user motivation versus lead user criteria [PDF]

, 2014
The past few years companies have become more interested in involving users during the production process of their products. On the other hand, a group of users started to innovate on their own.
Logghe, Sara, Oelbrandt, Kathy, Schuurman, Dimitri   +2 more
core   +1 more source

Sector coupling: accelerating renewable energy integration in transport with electric vehicles

Sustainable Earth Reviews
Energy and transport have long operated in ‘silos’, creating inefficiencies and conflicting goals. Breaking these silos through sector coupling links electricity and transport, aligning policies and actions to decarbonise mobility while boosting ...
Kanya Pranawengkapti, Shritu Shrestha, Stefan Werland, Emilie Martin, Oliver Lah   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source