Results 51 to 60 of about 913,122 (305)

Living Labs

Smart cities refer to place-specific collaborative systems where multiple actors collaborate to collectively address public problems. However, smart city initiatives regularly frame citizens as the weakest link, as passive consumers rather than active creative agents.
Anna Ståhlbröst, Mari Runardotter, Diana Chroneer, Zsuzsanna Bodí   +3 more
  +6 more sources

Living labs for in-situ open innovation: from idea to product validation and beyond [PDF]

, 2014
In this paper we present the Living Lab methodology as an overall framework for in-situ open innovation involving the end-user as equal participant in the innovation process.
Baccarne, Bastiaan, Coorevits, Lynn, De Meulenaere, Jonas, Georges, Annabel, Lievens, Bram, Schuurman, Dimitri, Vandenbroucke, Karel   +6 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Monitoring the Effects of Transboundary Water Pollution in Imperial Beach, California

Medical Sciences Forum
Transboundary water pollution is a major global challenge as its movement and impacts remain unsurveyed. Monitoring pollution along international borders can reveal some of the pathways by which sewage and chemicals enter water bodies, and can hence ...
Carol Maione, Domenico Vito, Gabriela Fernandez   +2 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Open innovation processes in living lab innovation systems: insights from the LeYLab [PDF]

, 2013
Living labs have emerged on the crossroads of the open innovation and user innovation frameworks. As open innovation systems, living labs consist of various actors with each playing their specific role.
Ballon, Pieter, De Marez, Lieven, Schuurman, Dimitri   +2 more
core   +1 more source

Quantifying subjective quality evaluations for mobile video watching in a semi-living lab context [PDF]

, 2012
This paper discusses results from an exploratory study in which Quality of Experience aspects related to mobile video watching were investigated in a semi-living lab setting.
De Marez, Lieven, De Moor, Katrien, De Pessemier, Toon, Joseph, Wout, Martens, Luc   +4 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Innovation is created by humans, not by systems: an exploration of user involvement in living labs: user motivation versus lead user criteria [PDF]

, 2014
The past few years companies have become more interested in involving users during the production process of their products. On the other hand, a group of users started to innovate on their own.
Logghe, Sara, Oelbrandt, Kathy, Schuurman, Dimitri   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source