Results 61 to 70 of about 913,122 (305)

Applying a Living Lab methodology to support innovation in education at a university in South Africa

open access: yesThe Journal for Transdisciplinary Research in Southern Africa, 2015
The Living Lab paradigm creates open and inter-disciplinary environments where participants can interrogate challenges and co-create solutions. A successful Living Lab context incorporates a clear focus/vision, strong leadership, self-sustainability, a ...
Ronel Callaghan, Marlien Herselman
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The relation between resident-related factors and care problems in nursing homes: a multi-level analysis

open access: yesBMC Health Services Research
Background Care problems such as decubitus and fall incidents are prevalent in nursing homes. Yet, research regarding explanatory factors on these care problems is scarce.
Suleyman Bouchmal   +4 more
doaj   +1 more source

Medical diagnostics using designed molecules with sense and logic [PDF]

open access: yes, 2013
Luminescent molecules responsive to cations, anions and even small molecules can be designed with the appropriate selectivity and sensitivity for monitoring physiological and pathological levels of analytes.
Cardona, Mario   +2 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Living labs as a driver for change in regional television [PDF]

open access: yes, 2014
Traditional television production and distribution organizations are increasingly being challenged by a rapidly changing technological environment. These evolutions force the television industry to leave their comfort zone. This context in mind, regional
Baccarne, Bastiaan, Schuurman, Dimitri
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Sector coupling: accelerating renewable energy integration in transport with electric vehicles

open access: yesSustainable Earth Reviews
Energy and transport have long operated in ‘silos’, creating inefficiencies and conflicting goals. Breaking these silos through sector coupling links electricity and transport, aligning policies and actions to decarbonise mobility while boosting ...
Kanya Pranawengkapti   +4 more
doaj   +1 more source

Living lab approach for developing massmarket IoT products and services [PDF]

open access: yes, 2014
Internet of Things (IoT) has emerged as a central concept in both the industrial as in the academic world. In this context, Living Lab research has been shown as an effective means for the design, implementation, development, testing and validation of ...
Schuurman, Dimitri, Vandenbroucke, Karel
core  

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