Results 51 to 60 of about 1,709,377 (255)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Is tagging with visual implant elastomer a reliable technique for marking earthworms? [PDF]

, 2009
Visual implant elastomer (VIE) has recently been employed to investigate different aspects of earthworm ecology. However, a number of fundamental questions relating to the detection and positioning of the tag, its persistence and potential effects on ...
BEN HAMOU M., BRENNAN N.P., BUTT K.R., Christopher Nathan Lowe, DYCKMANS J., GODIN D.M., GONZÁLEZ G., Kevin Richard Butt, LANGDON C.J., Maria Jesús Iglesias Briones, MAZAUD D., MORGAN J.E., SIMS R.W., SOUTHWOOD T.R.E., SPURGEON D.J.   +14 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Modular space station mockup review and evaluation [PDF]

The modular space station mockup is described in detail with emphasis on the interior arrangements of the crew living spaces, control center, and general purpose laboratory facilities.
Brockman, C. L., Schall, M. R., Jr.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Turbulent Diffusion and Turbulent Thermal Diffusion of Aerosols in Stratified Atmospheric Flows

, 2009
The paper analyzes the phenomenon of turbulent thermal diffusion in the Earth atmosphere, its relation to the turbulent diffusion and its potential impact on aerosol distribution.
Atreya, Bertaux, Blackadar, Brandenburg, Brasseur, Buchholz, Caporaloni, Chassaing, Collins, Csanady, Dalaudier, Eidelman, Eidelman, Eidelman, Elperin, Elperin, Elperin, Elperin, Elperin, Elperin, Elperin, Elperin, Elperin, et al., Fessler, Flagan, Friedlander, Fujiwara, Galperin, Genikhovich, I. Rogachevskii, Jensen, Khain, Kyrölä, M. Sofiev, Maxey, McComb, Moffatt, Monin, N. Kleeorin, Orszag, Pandya, Parameswaran, Pinsky, Pouquet, Reeks, Roberts, Rogachevskii, S. S. Zilitinkevich, Shaw, Sofiev, Sofiev, Sofieva, T. Elperin, V. Sofieva, Vanhellemont, Wang, Wyngaard, Yamamoto, Zilitinkevich, Zilitinkevich   +60 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effect of vegetation on sound fields in idealised urban open spaces [PDF]

, 2013
Noise pollution is a major environmental problem within the EU and during the last years vegetation was examined for its benefits in increasing health and well-being of citizens from different viewpoints, including noise control and soundscape ...
Astolfi, Arianna, Kang, J., Puglisi, Giuseppina Emma, Smyrnova, Y.   +3 more
core