Results 71 to 80 of about 1,709,377 (255)
University campuses as living laboratories
Urbis et Orbis Microhistory and Semiotics of the CityThe study explicates the methodology of living laboratories as open experiment spaces in real urban environment, which provide the development and testing of technological and social innovations in the city, contribute to the development of technological entrepreneurship and interdisciplinary communication, as well as strengthen emotional connection ...
N. B. Sedikova +3 more
openaire +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Moisture Performance Criteria for UK Dwellings [PDF]
, 2006 The new ventilation regulations in England and Wales have introduced performance criteria for the control of mould. The UK Government\'s Building Regulations Research Programme has funded University College London (UCL) to investigate the extent to which
Dejan Mumovic +5 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Application of LANDSAT to the surveillance and control of lake eutrophication in the Great Lakes basin [PDF]
The author has identified the following significant results. By use of distilled water samples in the laboratory, and very clear lakes in the field, a technique was developed where the atmosphere and surface noise effects on LANDSAT signals from water ...
Rogers, R. H.
core +1 more source
Living Crayfish in the Laboratory
The American Biology Teacher, 1969 T he crayfish is one of the most interesting living creatures that can be studied in high school biology. It not only has a variety of fascinating habits, but it is very easily observed and maintained in the laboratory. All of our crayfish are brought in by students.
openaire +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source