Results 81 to 90 of about 1,716,496 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Crystal Facet Engineering of 2D SnSe₂ Photocatalysts for Efficient Degradation of Malachite Green Organic Dyes

Nanomaterials
Wastewater containing triphenylmethane dyes such as malachite green (MG), discharged by textile and food industries, poses significant carcinogenic risks and ecological hazards.
Liying Wen, Fangfang Cheng, Xinyu Zhao, Lin Han, Dongye Zhao, Shifeng Wang   +5 more
doaj   +1 more source

Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

Scientific Reports, 2017
Contactin-4 (CNTN4) is a complex cell adhesion molecule (CAM) localized at neuronal membranes, playing a key role in maintaining the mechanical integrity and signaling properties of the synapse. CNTN4 consists of six immunoglobulin C2 type (IgC2) domains
Karolina Mikulska-Ruminska, Andrej J. Kulik, Carine Benadiba, Ivet Bahar, Giovanni Dietler, Wieslaw Nowak   +5 more
doaj   +1 more source

True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors

Cell Reports, 2018
Summary: Signaling nanodomains rely on spatial organization of proteins to allow controlled intracellular signaling. Examples include calcium release sites of cardiomyocytes where ryanodine receptors (RyRs) are clustered with their molecular partners ...
Isuru Jayasinghe, Alexander H. Clowsley, Ruisheng Lin, Tobias Lutz, Carl Harrison, Ellen Green, David Baddeley, Lorenzo Di Michele, Christian Soeller   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural Engineering in Sn-Doped WO₃ Multi-Phase Systems for Enhanced Transparent Heat Insulation

Molecules
Building energy conservation through the development of transparent thermal insulation materials that selectively block near-infrared radiation while maintaining visible light transmittance has emerged as a key strategy for global carbon neutrality.
Xinyu Song, Ze Wang, Yue Liu, Xin Li, Chun Du, Shifeng Wang   +5 more
doaj   +1 more source

Effect of vegetation on sound fields in idealised urban open spaces [PDF]

, 2013
Noise pollution is a major environmental problem within the EU and during the last years vegetation was examined for its benefits in increasing health and well-being of citizens from different viewpoints, including noise control and soundscape ...
Astolfi, Arianna, Kang, J., Puglisi, Giuseppina Emma, Smyrnova, Y.   +3 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Preparation of Lithium–Cesium Co-Doped Tungsten Oxide by Low-Temperature Hydrothermal Method

Nanomaterials
Buildings consume 40% of global energy, over half of which is used for cooling and heating. Tungsten bronze (MxWO3) holds promise for smart windows due to its ability to block near-infrared (NIR) heat radiation while maintaining visible light ...
Yue Liu, Xinyu Song, Liying Wen, Yan Luo, Zhiwang Sun, Shifeng Wang   +5 more
doaj   +1 more source