Results 131 to 140 of about 237,580 (299)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review. [PDF]
Yonsei Med J, 2022 Park Y +6 more
europepmc +1 more source
Facilitating Quintuple helix innovation with urban living labs [PDF]
, 2015 This paper discusses the Urban Living Lab approach as a way to put the Quintuple Helix model for innovation into practice. In this analysis we focus on the concepts innovation democracy, ‘mode 3’ knowledge production, the innovation ecosystem as a system
Baccarne, Bastiaan +2 more
core +1 more source
, 2018 This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne +5 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Methodology for Designing Smart Urban Living Labs from the University for the Cities of the Future. [PDF]
Sensors (Basel), 2021 Martínez-Bello N +3 more
europepmc +1 more source
Editorial : living labs and user innovation (January 2016) [PDF]
, 2016 Huizingh, Eelko +4 more
core +2 more sources
Action research as a framework to evaluate the operation of a living lab [PDF]
, 2016 Living lab research consists of gathering user feedback on innovations implemented in a real-life context (Eriksson et al., 2005). This can be facilitated by means of a panel-based approach (Schuurman et al., 2012).
Logghe, Sara, Schuurman, Dimitri
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source