Results 111 to 120 of about 237,979 (279)

Grand challenges and living labs: toward achieving the Sustainable Development Goals. [PDF]

Front Public Health, 2023
Molnar A, Lepenies R, Borda A, Pedell S.
europepmc   +1 more source

Generalization as local and translocal embedding: interrogating governance and deconstructing democratization in living labs

Sustainability: Science, Practice, & Policy
As societies scramble for ways to surmount current sustainability challenges, living labs have emerged as hopeful hybrid institutions to facilitate collaboration.
Julia Backhaus, Stefan John
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Innovation through the Quintuple Helix in living labs: lessons learned for a transformation from lab to ecosystem. [PDF]

Front Public Health, 2023
Merino-Barbancho B, Abril Jiménez P, Mallo I, Lombroni I, Cea G, López Nebreda C, Cabrera MF, Fico G, Arredondo MT.   +8 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Living labs for civic technologies: a case study. Community infrastructuring for a volunteer firefighting service. [PDF]

Front Public Health, 2023
Viano C, Tsardanidis G, Dorato L, Ruggeri A, Zanasi A, Zgeras G, Mylona V, Efthymiou I, Vlachokyriakos V.   +8 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Urban living labs as innovation infrastructure for local urban intervention acceleration and student social learning: the impacts on community wellbeing in Heerlen. [PDF]

Front Public Health, 2023
Blezer S, Abujidi N, Sap H.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Urban Living Labs: how to enable inclusive transdisciplinary research? [PDF]

Urban Transform, 2021
Laborgne P, Ekille E, Wendel J, Pierce A, Heyder M, Suchomska J, Nichersu I, Balaican D, Ślebioda K, Wróblewski M, Goszczynski W.   +10 more
europepmc   +1 more source