Results 131 to 140 of about 2,001,979 (250)
Protocol for a systematic review of living labs in healthcare. [PDF]
BMJ Open, 2021 Archibald M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review. [PDF]
Yonsei Med J, 2022 Park Y +6 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A Methodology for Designing Smart Urban Living Labs from the University for the Cities of the Future. [PDF]
Sensors (Basel), 2021 Martínez-Bello N +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The social living labs methodology for fostering digital participation in regional and rural Australian communities [PDF]
, 2016 This paper outlines the methodology being used in the Australian Research Council Funded Linkage project, Fostering Digital Participation through Living Labs in Regional and Rural Australia.
Hughes, Hilary E., Dezuanni, Michael L.
core
How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? [PDF]
Philos Ethics Humanit Med, 2021 Sacco G +7 more
europepmc +1 more source