Results 131 to 140 of about 237,979 (279)

Living labs as orchestrators in the regional innovation ecosystem: a conceptual framework

Journal of Responsible Innovation
This research explores the conceptual integration of Living Labs (LLs) into the Regional Innovation Ecosystem (RIE) to understand their potential as facilitators of Responsible Innovation.
Janin Fauth, Kevin De Moortel, Dimitri Schuurman   +2 more
doaj   +1 more source

Getting personal: exploring the usage of persona in order to optimize the involvement of a living lab panel [PDF]

, 2015
iMinds Living Labs started with living lab research in 2009. Living lab research involves gathering user feedback on innovations implemented in a real-life context (Eriksson et al., 2005).
Logghe, Sara
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Protocol for a systematic review of living labs in healthcare. [PDF]

BMJ Open, 2021
Archibald M, Wiebe S, Rieger K, Linton J, Woodgate R.   +4 more
europepmc   +1 more source

Innovation is created by humans, not by systems: an exploration of user involvement in living labs: user motivation versus lead user criteria [PDF]

, 2014
The past few years companies have become more interested in involving users during the production process of their products. On the other hand, a group of users started to innovate on their own.
Logghe, Sara, Oelbrandt, Kathy, Schuurman, Dimitri   +2 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Digital Biomarkers in Living Labs for Vulnerable and Susceptible Individuals: An Integrative Literature Review. [PDF]

Yonsei Med J, 2022
Park Y, Go TH, Hong SH, Kim SH, Han JH, Kang Y, Kang DR.   +6 more
europepmc   +1 more source

A Secure Data Publishing and Access Service for Sensitive Data from Living Labs: Enabling Collaboration with External Researchers via Shareable Data

Big Data and Cognitive Computing
Intending to enable a broader collaboration with the scientific community while maintaining privacy of the data stored and generated in Living Labs, this paper presents the Shareable Data Publishing and Access Service for Living Labs, implemented within ...
Mikel Hernandez, Evdokimos Konstantinidis, Gorka Epelde, Francisco Londoño, Despoina Petsani, Michalis Timoleon, Vasiliki Fiska, Lampros Mpaltadoros, Christoniki Maga-Nteve, Ilias Machairas, Panagiotis D. Bamidis   +10 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source