Results 91 to 100 of about 237,979 (279)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Living Labs as a Form of Innovation Development
Management and Business Administration. Central Europe, 2013 Purpose: The general purpose of this paper is to present living labs as a new form of innovation activity based on the concept of user-driven innovation. More specifi c goals are to show the development of living labs around the world and to identify the
Wanda Pełka
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Living Labs as Tools for Open Innovation [PDF]
This paper presents a Living Lab in Stockholm as a focal point for discussing how the Living Lab concept can be extended and used for engaging in multiorganizational open innovation.
Håkan OZAN +3 more
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Positioning urban labs – a new form of smart governance? [PDF]
, 2016 In the current era, in which cities are considered key arenas for coping with a number of societal challenges, there is also renewed interest in the mobilisation of experimental practices within urban planning. A growing interest in innovative intiatives
Perjo, Liisa +3 more
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Public policy labs in European Union members states [PDF]
, 2016 Policy Labs are emerging structures that construct public policies in an innovative, design-oriented fashion, in particular by engaging citizens and companies working within the public sector.
FULLER MATT, LOCHARD ANNA
core +2 more sources
Suomen Maataloustieteellisen Seuran Tiedote, 2010 Käytettävyys on tuotteen ominaisuus, joka määrittelee, kuinka hyvin tuote vastaa tavoiteltua käyttötarkoitustaan ja kuinka hyvin käyttäjä pystyy hyödyntämään tuotteen toimintoja. Hyvä käytettävyys havaitaan mm. tuotteen käytön helppoutena, nopeutena ja miellyttävyytenä.
Esala, Jussi, Kankaanpää, Sanna
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Looper: Towards a Methodology of Co-Design Approaches [PDF]
, 2018 When setting up their own participatory process, researchers and citizens alike are confronted with a wide array of online and offline tools targeted towards facilitating co-creation.
Keseru, Imre +2 more
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