Results 91 to 100 of about 2,001,979 (250)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Why collaborate in long-term innovation research? An exploration of user motivations in Living Labs [PDF]
, 2013 One of the central elements of Living Labs is the focus on end user involvement in IT-product and service development processes (Ståhlbröst, 2008; Ståhlbröst et al., 2009).
Schuurman, Dimitri +3 more
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
131154Living Labs for Sustainable Development aim to generate low-resource innovations in production-consumption systems by integrating users and actors. This chapter presents the results of a German study investigating potentials of and measures towards
Rohn, Holger +4 more
core +1 more source
Living labs and building testing labs: enabling climate change adaptation
Buildings & CitiesClimate action requires rapid, evidence-based and locally appropriate adaptation measures. Effective responses in the built environment depend on integrated, multilevel solutions developed through inter- and transdisciplinary collaboration.
Jan Hugo, Maryam Farhadian
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2019 FRANÇAIS Initiés à la fin des années 1990 au M.I.T. Media Lab, créés en France en 2006 avec le Manifeste d’Helsinki sous la présidence finlandaise de l’Union Européenne, les Living Labs apparaissent comme une nouvelle approche de l’innovation.
c2l3play
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source