Results 81 to 90 of about 237,979 (279)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Responsible Research and Innovation-Labs: towards new forms of reflexivity in engineering and innovation practices

Journal of Responsible Technology
This article explores the integration of Responsible Research and Innovation (RRI) principles within living labs, particularly focusing on engineering and innovation practices.
René von Schomberg, Stefan Böschen, Julia Backhaus   +2 more
doaj   +1 more source

CIKM 2013 workshop on living labs for information retrieval evaluation [PDF]

, 2013
In the past few years the information retrieval (IR) community has been exploring ways to move further away from the Cranfield style evaluation paradigm, and make evaluations more ‘realistic’ (more centered on real users, their needs and behaviours).
Balog, Krisztian, Elsweiler, David, Kanoulas, Evangelos, Kelly, Liadh, Smucker, Mark   +4 more
core  

Living labs in architecture as innovation arenas within higher education institutions [PDF]

, 2017
Education at schools of architecture must attend the demand for a new profile for architects, integrating and fostering corresponding SD competences through new learning methodologies, tools and concepts.
Masseck, Torsten
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Innovation from user experience in Living Labs: revisiting the ‘innovation factory’-concept with a panel-based and user-centered approach [PDF]

, 2012
This paper focuses on the problem of facilitating sustainable innovation practices with a user-centered approach. We do so by revisiting the knowledge-brokering cycle and Hargadon and Sutton’s ideas on building an ‘innovation factory’ within the light of
Ballon, Pieter, De Marez, Lieven, Lievens, Bram, Schuurman, Dimitri   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Watershed Approach to Co-Creating Just Sustainabilities: Reflections from the Lake Superior Living Labs Network

Interdisciplinary Journal of Partnership Studies
Campus-community partnerships are well-positioned to play a role in advancing social and environmental justice in the context of our rapidly changing and increasingly inequitable world. Across the Global North, post-secondary institutions, civil society
Charles Z. Levkoe, Nairne Cameron, Lindsay P. Galway , Rachel L. W. Portinga , Randy Hanson , Kathryn Milun , Erika Vye   +6 more
doaj   +1 more source