Results 81 to 90 of about 2,001,979 (250)

Combining User and Context: Living Labs Innovation in Digital Services [PDF]

, 2014
With the continuous advances of Information and Communication Technology (ICT) such as Ubiquitous Computing, Mobile Computing and the Internet of Things (IoT), users' living contexts and daily life activities are increasingly digitalized.
Tang, Tingan
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Integrated Impact Assessment of Living Labs. Conceptual Framework, Approach and Methods applied in the LANTERN project [PDF]

, 2023
Switzerland aims for net-zero greenhouse gas emissions by 2050. Against this background, the LANTERN project uses urban Living Labs to co-design, test, validate, and scale up a portfolio of interventions that can contribute to a more user-empowered ...
Moser, Stephanie, Piana, Valentino, Rosset, Jan, Grieder, Manuel, Yilmaz, Selin, Boogen, Nina, Bär, Roger   +6 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Watershed Approach to Co-Creating Just Sustainabilities: Reflections from the Lake Superior Living Labs Network

Interdisciplinary Journal of Partnership Studies
Campus-community partnerships are well-positioned to play a role in advancing social and environmental justice in the context of our rapidly changing and increasingly inequitable world. Across the Global North, post-secondary institutions, civil society
Charles Z. Levkoe, Nairne Cameron, Lindsay P. Galway , Rachel L. W. Portinga , Randy Hanson , Kathryn Milun , Erika Vye   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fostering digital participation and communication through social living labs: a qualitative case study from regional Australia [PDF]

, 2017
This qualitative case study explores the potential of social living labs to foster digital participation and communication among regional and rural communities.
Cherie Allan, Hughes, Hilary, Mallan, Kerry, Allan, Cherie, Foth, Marcus, Michael Dezuanni, Kerry Mallan, Dezuanni, Michael L., Hilary Hughes, Marcus Foth   +9 more
core   +1 more source

Living Labs as a Form of Innovation Development

Management and Business Administration. Central Europe, 2013
Purpose: The general purpose of this paper is to present living labs as a new form of innovation activity based on the concept of user-driven innovation. More specifi c goals are to show the development of living labs around the world and to identify the
Wanda Pełka
doaj  

A Small-Firm Perspective on the Benefits of Living Labs [PDF]

Technology Innovation Management Review, 2012
Decreasing energy consumption is a global priority and the energy market is in constant change. The search for energy-saving innovations provides an opportunity to initiate a user-centered approach using the living labs model.
Veli-Pekka Niitamo, Mika Westerlund, Seppo Leminen   +2 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source