Results 71 to 80 of about 2,001,979 (250)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Urban Living Labs: A living lab way of working
, 2017 Urban living labs have become a popular phenomenon in today’s cities. The Living Lab approach would provide real life research with its multiple stakeholders in a co-innovating inclusive setting, crucial in creating metropolitan solutions with impact ...
van Bueren, Ellen +3 more
core +1 more source
Intersecting governance logics in living labs: beyond governance tensions?
Urban TransformationsLiving labs are increasingly used to support collaborative experimentation and innovation in urban contexts. However, their integration into established public governance may create tensions between collaborative and traditional governance.
Stefan Bernat, Anna Yström
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2016 In this paper we critically assess the attempts of the Amsterdam University of applied Sciences (AUAS) to facilitate social innovation through living labs.
van der Heijden, Elke +3 more
core
Trans-city data integration platforms: an explorative study on Smart Dublin and Torino City Lab.
, 2022 This paper contributes to the literature on living labs, innovation ecosystems, and the transformation to smart and sustainable cities by exploring the use of a trans-city data integration platform on the smart city programs Smart Dublin and Turin City
Matteo Spinazzola +7 more
core
Journal of Responsible TechnologyThis article explores the integration of Responsible Research and Innovation (RRI) principles within living labs, particularly focusing on engineering and innovation practices.
René von Schomberg +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source