Results 71 to 80 of about 237,979 (279)

Nachhaltigkeitsanforderungen und -bewertung in Living Labs: Konzeption eines Bewertungsmodells : Arbeitspapier im Arbeitspaket 2 (AS 2.1) im INNOLAB Projekt "Living Labs in der Green Economy: realweltliche Innovationsräume für Nutzerintegration und Nachhaltigkeit" [PDF]

, 2016
Das Thema dieses Papieres ist die Integration von Nachhaltigkeitskriterien in den Innovationsprozess von Living Labs. Es wurde ein Bewertungsmodell entwickelt, welches den Innovationsprozess in Living Labs zu strukturieren hilft, indem die Anforderungen ...
Echternacht, Laura, Führer, Julia, Geibler, Justus von, Hasselkuß, Marco, Liedtke, Christa, Piwowar, Julius, Rösch, Ramona, Stadler, Karin, Wirges, Monika   +8 more
core  

Open Innovations and Living Labs: Promises or Challenges to Regional Renewal [PDF]

, 2013
The paper brings to the foreground modes and strategies of organising purposeful action that may be conductive to local and regional actors’ successful coping in the more and more competitive environment.
Karppi, Ilari
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Marco metodológico para la implementación y evaluación de Living Labs [PDF]

, 2008
El Living Lab constituye un enfoque de investigación para la innovación que desafía todo el proceso de innovación e investigación en condiciones de la vida real mediante aspectos institucional, organizacional, cultural, social y humano, teniendo un ...
García Guzmán, Javier
core   +1 more source

Report on the CIKM workshop on living labs for information retrieval evaluation [PDF]

, 2014
Evaluation is a central aspect of information retrieval (IR) research. In the past few years, a new evaluation methodology known as living labs has been proposed as a way for researchers to be able to perform in-situ evaluation.
Balog, Krisztian, Elsweiler, David, Kanoulas, Evangelos, Kelly, Liadh, Smucker, Mark   +4 more
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Living Labs for SMEs [PDF]

Interactive, co-creative relation of consumers, users and producers is quickly developing recently. Living Labs (LL) have a bridging role between market pull and technology push. They realise concurrent innovation.
György Kadocsa, Imre Hronszky Dr., Katalin Kovács   +2 more
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