Results 51 to 60 of about 237,580 (299)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Living Labs

Smart cities refer to place-specific collaborative systems where multiple actors collaborate to collectively address public problems. However, smart city initiatives regularly frame citizens as the weakest link, as passive consumers rather than active creative agents.
Anna Ståhlbröst, Mari Runardotter, Diana Chroneer, Zsuzsanna Bodí   +3 more
  +6 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mastering Participatory Living Labs

Proceedings of: Tagung Zukünftige Stromnetze - Future Power Grids Conference
This paper presents the concept and implementation of participatory living labs in the context of the unIT-e² project, which aims to integrate electromobility into the energy system efficiently.
Jeremias Hawran, Daniela Wohlschlager
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A framework for analyzing the role of living labs in smart cities: insights from a case study in Japan

Discover Sustainability
Living labs integrated into smart city development offer promising strategies for citizen engagement and participatory urban planning. This study introduces a comprehensive framework for quantitatively analyzing living labs' impact on citizens ...
Jooho Park, Kentaro Watanabe, Fumiya Akasaka, Sayaka Fujii   +3 more
doaj   +1 more source

Overcoming barriers to experimentation in business-to-business living labs [PDF]

, 2017
Business-to-business (B2B) living lab projects have been mentioned in different areas of academic research, but the innovation management literature requires deeper analysis of their potential opportunities and challenges.
Ballon, Pieter, Coorevits, Lynn, D'Hauwers, Ruben, Georges, Annabel, Herregodts, Aron-Levi, Rits, Olivier, Schuurman, Dimitri   +6 more
core   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source