Results 91 to 100 of about 802,900 (310)
Background: Anxiety is a prevalent psychological comorbidity among people living with HIV/AIDS (PLWHA), contributing to impair social functioning and reduced quality of life.
Dr. Ishrat Yousaf +5 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Electrochemical water splitting for hydrogen production is considered a key pathway for achieving sustainable energy conversion. However, the sluggish reaction kinetics of the oxygen evolution reaction (OER) and high overpotentials severely hinder the ...
Ze Wang +6 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Harnessing Technology and Citizen Science to Support Neighborhoods that Promote Active Living in Mexico [PDF]
Lisa G. Rosas +6 more
openalex +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Background Covid 19 was declared as a public health emergency by the World Health Organisation (WHO) due to its rapid spread and catastrophic effects on health.
Rakhshi Memon +9 more
doaj +1 more source
A Case Study of a Natural Experiment Bridging the 'Research into Policy' and 'Evidence-Based Policy' Gap for Active-Living Science. [PDF]
Hooper P, Foster S, Giles-Corti B.
europepmc +1 more source

