Results 51 to 60 of about 5,963,455 (274)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Safety Life Space of Ukrainians: Analysis of Subjective Opinions

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Соціологічні дослідження сучасного суспільства: методологія, теорія, методи, 2020
The article is devoted to the analysis of the data of numerous empirical sociological studies of domestic scientists about the subjective assessments of Ukrainians of the safety of their living space. It is emphasized that the living space of a person is
Lyudmila Kalashnikova
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The combined 410nm and infrared light effectively suppresses bacterial survival under realistic conditions

Frontiers in Cellular and Infection Microbiology
The demand for establishing an effective but inexpensive method to interfere with the spread of infectious diseases has been higher than ever before, since the recent pandemic.
Matthew Stangl, Matthew Stangl, Dinesh Kumar Verma, Dinesh Kumar Verma, Areli Martinez, Yong-Hwan Kim, Yong-Hwan Kim   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Forest as A Living Space: Rulership and Management in the Tenganan Pegringsingan Customary Forest, Karangasem Regency, Bali

Jurnal Ilmu Kehutanan
Humans control their cultural environment, which is associated with biotic and abiotic environments, resulting in environmental sustainability. The indigenous community's existence in managing environmental resources must be examined more deeply from the
Aloysius Gonzaga Dimas Bintarta Raharja, Muhammad Baiquni, Setiadi Setiadi   +2 more
doaj   +1 more source

Living In A Prototype

Proceedings of the 2016 CHI Conference on Human Factors in Computing Systems, 2016
In this paper, we present a twenty-three months autobiographical design project of converting a Mercedes Sprinter van into a camper van. This project allows us to investigate the complexities and nuances of a case where people engage in a process of making, transforming and adapting a space they live in.
Audrey Desjardins, Ron Wakkary
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

LIVING IN CURVED MOMENTUM SPACE [PDF]

International Journal of Modern Physics A, 2013
In this paper, we review some aspects of relativistic particles' mechanics in the case of a nontrivial geometry of momentum space. We start by showing how the curved momentum space arises in the theory of gravity in 2+1 dimensions coupled to particles, when (topological) degrees of freedom of gravity are solved for.
openaire   +2 more sources