Results 131 to 140 of about 2,046,162 (340)

Disinfection of Burkholderia pseudomallei in potable water

, 2005
The effect of chlorine, monochloramine and UV disinfection on the water-borne pathogen Burkholderia pseudomallei was assessed. Persistence of B. pseudomallei was verified by MPN involving a one-step recovery procedure.
Howard, K., Inglis, T.J.J.
core  

Failed intentions? Meeting the water needs of people living with HIV in South Africa

, 2020
Researchers, activists, practitioners and policy-makers have grappled with the challenge of providing people living with HIV (PLHIV) with an adequate amount of safe water.
Mary Galvin, Galvin, Mary, Masombuka, Linah N., Linah N Masombuka   +3 more
core   +1 more source

Improving Water Quality by Combined Sedimentation and Slow Sand Filtration: A Case Study in a Maasai Community, Tanzania

Applied Sciences
Some Maasai communities in northern Tanzania face severe water quality and scarcity issues, significantly impacting the health and living conditions of the local population.
Nadav Bachar, Noga Lindenstrauss, Saar David, Micha Mirkin, Noam Polani, Osher Gueta, Shaked Partush, Avner Ronen   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Demographic, economic and social drivers

, 2009
Key Messages: (1) Human activities and processes of all types -- demographic, economic and social -- can exert pressures on water resources and need to be managed.
Bjoerklund, G., Warner, K., Winpenny, J., Connor, R., Moriarty, P., Goujon, A., Hellmuth, M., Rast, W.   +7 more
core  

The role of water markets in climate change adaptation [PDF]

, 2013
Water markets were first introduced in Australia in the 1980s, and water entitlement and allocation trade have been increasingly adopted by both private individuals and government.Irrigators turned to water markets (particularly for allocation water) to ...
Adam Loch, Simon Beecham, Henning Bjornlund   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Biological testing of ships’ ballast water indicates challenges for the implementation of the Ballast Water Management Convention

Frontiers in Marine Science
Ships’ ballast water and sediments are vectors that contribute to the unintentional spread of aquatic non-native species globally. Ballast water management, as well as commissioning testing of ballast water management systems and compliance monitoring ...
Okko Outinen, Sarah A. Bailey, Oscar Casas-Monroy, Stephanie Delacroix, Sonia Gorgula, Evelina Griniene, Jenni E. Kakkonen, Greta Srebaliene   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source