Results 201 to 210 of about 15,916,154 (299)

Editorial: Microbial ecology supporting growth of free-living amoebae in natural and engineered water systems

Frontiers in Microbiology
Elliott P. Barnhart, Isabel Douterelo, Matthew J. Morgan, Geoffrey J. Puzon   +3 more
doaj   +1 more source

Kidney Health for all: Caring for People, Protecting the Planet. [PDF]

Can J Kidney Health Dis
Vanholder R, Abdellatif D, Dos Santos ACS, Correa-Rotter R, Gopalakrishnan N, Wang B, Roumeliotis S, Balducci A, Haris Á, Yadla M, Hsiao LL.   +10 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

An annotated checklist of free-living Copepoda (Crustacea) of Iraq: diversity, distribution, and biogeographical affinities. [PDF]

Zookeys
Naser M, Yasser A, Karpowicz M, de Los Ríos-Escalante PR.   +3 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Engineering cyanobacterial resilience for cadmium bioremediation: linking Cd speciation, cellular detoxification, and synthetic biology. [PDF]

RSC Adv
Ali S, Ilyas T, Touzout N, Shahid M, Farooqui A, Almalki MA, Alfredan M, Hag Ibrahim RI.   +7 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source