Results 31 to 40 of about 284,893 (258)

Living within the safe and just Earth system boundaries for blue water

Nature Sustainability, 2023
Abstract Safe and just Earth system boundaries (ESBs) for surface water and groundwater (blue water) have been defined for sustainable water management in the Anthropocene. Here we assessed whether minimum human needs could be met with surface water from within individual river basins alone and, where this is not possible, quantified ...
Ben Stewart‐Koster, Stuart E. Bunn, Pamela A. Green, Christopher E. Ndehedehe, Lizzi Andersen, David I. Armstrong McKay, Xuemei Bai, Fabrice DeClerck, Kristie L. Ebi, Christopher J. Gordon, Joyeeta Gupta, Syezlin Hasan, Lisa Jacobson, Steven J. Lade, Diana Liverman, Sina Loriani, Awaz Mohamed, Nebojša Nakićenović, David Obura, Dahe Qin, Crelis Rammelt, Juan Rocha, Johan Rockström, Peter H. Verburg, Caroline Zimm   +24 more
openaire   +4 more sources

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Polychaete annelids as live bait in Portugal: Harvesting activity in brackish water systems

Ocean & Coastal Management, 2019
Abstract Polychaete annelids are some of the most heavily harvested invertebrates collected in coastal areas and estuaries for their economic value as live fishing bait or as food supplement in aquaculture activities. However, information on bait digging in Portugal is scarce or incomplete.
Cabral, Sara, Alves, Ana Sofia, Castro, Nuno, Chainho, Paula, Sá, Erica, Cancela Da Fonseca, Luís, Fidalgo e Costa, Pedro, Castro, João, Canning-Clode, João, Pombo, Ana, Costa, José Lino   +10 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Evaluating the Drinking Water Distribution System of Lahore for Free-Living Amoebas, Particularly Naegleria spp.

Journal of Parasitology Research
Free-living amoebas are ubiquitous in distribution systems and recreational waters. Numerous studies have described the problem posed by their presence in the drinking water distribution systems of Lahore; however, very few studies have been done on ...
Ayesha Najam, Sana Ullah Iqbal, Waqas Ahmed, Rabia Tanvir, Haroon Akbar   +4 more
doaj   +1 more source

Drivers for the adoption of circular water systems at the building level in a high-income context

Water Research X
Circular water systems at the building level offer potential for sustainable water management. Yet, user acceptance and willingness to pay (WTP) challenge their adoption. This study explores factors shaping acceptance and WTP by surveying 496 respondents
Devi Buehler, Laila Luethi, Diederik P.L. Rousseau, Alice H. Aubert, Martina Bozzola   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source