Results 51 to 60 of about 2,046,162 (340)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Multi-objective optimization of integrated water reuse systems at a cluster scale

, 2010
Population growth and higher standards of living have and will continue to drive an increasing demand for water supplies. Past practices have seen conventional water sources diminish which has lead to environmental degradation.
Brock, C., McGregor, C., Colsey, C., Russo, E., Maier, H., Dandy, S.   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A review of Ancient Roman water supply exploring techniques of pressure reduction. [PDF]

, 2007
The Ancient Roman water supply systems still leave us astonished when admiring the solidity of the ruins of aqueducts surviving around Europe. Some parts of these systems are still in use at present and prove the practical efficiency of Roman hydraulics ...
Yeung, Hoi, Monteleone, M. C., Smith, Richard   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Legionella control in water systems using copper and silver ion generation systems [PDF]

, 2012
Legionella can cause human disease which can be fatal. Routine monitoring for Legionella in water systems is not recommended by UK authorities. Evidence of the efficacy of control modalities against Legionella in these water systems is, therefore, not
Bedford, Birgitta
core  

Polychaete annelids as live bait in Portugal: Harvesting activity in brackish water systems

Ocean & Coastal Management, 2019
Abstract Polychaete annelids are some of the most heavily harvested invertebrates collected in coastal areas and estuaries for their economic value as live fishing bait or as food supplement in aquaculture activities. However, information on bait digging in Portugal is scarce or incomplete.
Cabral, Sara, Alves, Ana Sofia, Castro, Nuno, Chainho, Paula, Sá, Erica, Cancela Da Fonseca, Luís, Fidalgo e Costa, Pedro, Castro, João, Canning-Clode, João, Pombo, Ana, Costa, José Lino   +10 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Evaluating the Drinking Water Distribution System of Lahore for Free-Living Amoebas, Particularly Naegleria spp.

Journal of Parasitology Research
Free-living amoebas are ubiquitous in distribution systems and recreational waters. Numerous studies have described the problem posed by their presence in the drinking water distribution systems of Lahore; however, very few studies have been done on ...
Ayesha Najam, Sana Ullah Iqbal, Waqas Ahmed, Rabia Tanvir, Haroon Akbar   +4 more
doaj   +1 more source