Results 51 to 60 of about 284,893 (258)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Shaping Water Infrastructure Futures in the European Union Context
EncyclopediaThis entry explores how foresight approaches can guide the future of water infrastructures. It highlights key long-term disruptive drivers of change—such as climate change, digital transformation, and geopolitical tensions—that infrastructures must ...
Helena Alegre
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of living shorelines as a resilience strategy for nutrient reduction in estuarine systems
Frontiers in Marine ScienceIntroductionTidal salt marshes provide critical ecosystem services in estuaries including the removal, storage, and transformation of nutrients, improving water quality and aquatic habitat. As tidal marshes drown from sea level rise, this service is lost,
Emma Dodsworth +4 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The biological impact of deuterium and therapeutic potential of deuterium-depleted water
Frontiers in PharmacologySince its discovery by Harold Urey in 1932, deuterium has attracted increased amounts of attention from the scientific community, with many previous works aimed to uncover its biological effects on living organisms.
Jiao Qu +8 more
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Organometallic Chemistry in Non-Classical Environments
CHIMIA, 2011 A summary of our on-going research on organometallic chemistry is provided with an emphasis on the function, reactivity and mechanisms of organometallic compounds in water, ionic liquids and in living systems.
Paul J. Dyson
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
International Journal of Anthropology and EthnologyIndia faces its worst water crisis, with 600 million people under extreme water stress and 70% of its water contaminated. Amid this crisis, the traditional water infrastructures of the Braj region, steeped in Vedic cultural heritage, offer valuable ...
Anupama Bharti
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