Results 161 to 170 of about 1,974,145 (268)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Why does hepatitis B remain underprioritized? A view through lived experience. [PDF]

World J Methodol
Ibrahim Y, Qureshi A, Jackson M, Zovich B, Freeland C, Flomo M, Alik K, Yakubov R, Chen LH, Yeboah PK, Cohen C.   +10 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Bioethics and health law: the living will. Proposal to create a living will record in Europe

, 2012
In this piece of work, we present a proposal to create a living will record in Europe that will allow people to have the same rights wherever they are.
Díez Rodríguez, José Ramón, Marcos del Cano, Ana Maria   +1 more
core  

Effects of HIV and Adverse Childhood Experiences on Neurocognition. [PDF]

J Acquir Immune Defic Syndr
Inman EM, Inman EM, Ramsammy CW, Kalegina A, Robbins RN, Violari A, Kidman R.   +6 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Introduction to the smart living building concept

Constructing the smart living building means producing a building ahead of its time, since it will respond to goals set for the year 2050. Nowadays, a person consumes in average 5,500 watts.
Jusselme, Thomas
core  

Just me and my radio

, 2015
Gift of Dr. Mary Jane Esplen.As featured by Will Osborne over station WABC every sat. night at 7pm [note]Piano vocal ukulele [instrumentation]Living alone [first line]When I feel blue [first line of chorus]G [key]Moderato [tempo]Popular song [form/genre ...
Osborne, Will [composer], Woods, Al [lyricist]   +1 more
core  

Patient and physician preferences for treatment of hepatitis C virus infection in Japan: a discrete choice experiment: plain language summary of publication. [PDF]

Ther Adv Gastroenterol
Nakamoto D, Piao Y, Yoshida M, LoPresti M, Makhija D, Kwon KM, Zagorski J, Jinushi M, Eguchi Y.   +8 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source