Results 181 to 190 of about 13,837,613 (303)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Lives lived

BMJ, 2007
openaire   +2 more sources

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

New horizons in cooking and mealtime interventions for mild cognitive impairment and early dementia: a scoping review. [PDF]

J Nutr Health Aging
Bannon SM, Elizalde Carrillo R, McCage S, Shahab MH, Allison GO, Aminpour A, Levinson C, Presciutti AM, Fishel A.   +8 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Living evidence map of the global climate and health literature. [PDF]

Cochrane Database Syst Rev
Metzendorf MI, Callaghan M, Finnerty Mutlu A, Gopal I, Hair K, Kawooya I, Lusiba P, Mena Mora A, Nduku PM, Noel-Storr A, Okwen MP, Pita Vaca I, Pontes M, Repke T, Scheelbeek P, Schmidt L, Soliman N, Jeppesen BT, Thomas J, Wung AE, Minx J, supported by the Cochrane Planetary Health Thematic Group.   +21 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Results from the VANISH study: A prospective multicenter study validating a single-nucleotide polymorphism-based noninvasive prenatal test to assess aneuploidy risk in surviving twins of vanishing twin pregnancies. [PDF]

Pregnancy (Hoboken)
Dugoff L, Mumford SL, Rochon ML, Chavez M, Kohari K, Scholl JE, Berkin JA, Roman AS, Chueh J, Wolf SB, Palomares KTS, Hurt KJ, Wapner RJ, Gorman K, Wick MJ, Savasan ZA, Platt LD, Treadwell MC, Al-Khan A, Livingston JM, Hoffman MK, Rabin-Havt SS, Rabinowitz M, Ahmed E, Saben JL, Sun N, Butskova A, Xu W, Meltzer J, Souter V.   +29 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A long journey from Intensive Care to Pain. Interview to Renato Coluccia

Pathos, 2009
Mara Sala
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