Results 61 to 70 of about 1,731,944 (253)

Advance directive: does the GP know and address what the patient wants? Advance directive in primary care

BMC Medical Ethics, 2018
Background Due to the rapid changes in the medical world and the aging population, the need for advanced care planning grows. Despite efforts to make this topic discussed, only a minority of patients discusses the advance directive with their general ...
Guda Scholten, Sofie Bourguignon, Anthony Delanote, Bieke Vermeulen, Geert Van Boxem, Birgitte Schoenmakers   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Evaluation of a Community-Based Advance Care Planning Campaign for a General Adult Population

Palliative Medicine Reports
Background: Early advance care planning (ACP) has been widely recommended, but overall uptake remains low. Most efforts to improve formal ACP adoption, namely living will (LW) and health care agent (HCA) documentation, focus on medical settings targeted ...
Peiyuan Zhang, Tiffany C. Erbelding, Glenn E. Schneider, Nikki Highsmith Vernick, John G. Cagle   +4 more
doaj   +1 more source

Advanced directives: open issues

Italian Journal of Medicine, 2013
BACKGROUND In Italy Advanced directives have not been regulated by law yet. Moreover, there is a confusion of concepts: advanced directives, refusal of treatment, medical futility and euthanasia are not synonymous.DISCUSSION The following aspects are ...
Gabriella Negrini
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Development of knowledge⁃attitude⁃practice(KAP) questionnaire on living will of elderly patients and its reliability and validity test

Huli yanjiu, 2020
ObjectiveTo develop knowledge⁃attitude⁃practice（KAP） questionnaire on living will of elderly patients，and to test its reliability and validity.MethodsWith framework of knowledge⁃attitude⁃practice（KAP） theory，knowledge⁃attitude⁃practice（KAP） questionnaire
ZHANG Yanting, QIAN Xinyi, LI Jianjun
doaj  

Are we Living an Illusion? Folk Intuitions on the Problem of Free Will

Rivista Internazionale di Filosofia e Psicologia, 2015
In recent years, philosophy has witnessed the birth and development of a new research program that has provoked both enthusiasm and strong criticism: Experimental Philosophy (or X-Phi).
Silvia Felletti
doaj   +1 more source