Results 151 to 160 of about 605,324 (246)

The Src inhibitor peptide TAT-Cx43_266-283 improves survival in an intracranial murine model of lung cancer brain metastasis. [PDF]

Neurooncol Adv
Cerveró-García P, Jiménez-Madrona E, Álvarez-Vázquez A, Flores-Hernández R, García-Vicente L, García-Guerrero L, Alonso-Amador JJ, González-Sánchez R, Ollauri-Ibáñez C, Paniagua-Sancho M, Talaverón R, Rodrigues-Teixeira T, Martín-Guerrero SM, Casado P, Rajeeve V, Shields T, Hijazi M, Cutillas PR, Jaraíz-Rodríguez M, Tabernero A.   +19 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Microwave ablation combined with dendritic cells enhances CD8⁺ T cell activation in rechallenged tumor mouse model. [PDF]

Cancer Immunol Immunother
Ma J, Xu F, Wang M, Zhang S, Sang J, Chen H, Wen F, Ge R, Xie Q, Wei Z, Ye X.   +10 more
europepmc   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

Advanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen, Ioannis Ziogas, Shirina Alsaedi, Mouza Alshehhi, Shahd Almheiri, Adil Rehman, Khulood Al Shehhi, Hani Saleh, Ahsan Khandoker, Charalampos Pitsalidis, Antoun Khawaja, Anna‐Maria Pappa   +11 more
wiley   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

SLC2A1⁺ tumour-associated macrophages spatially control CD8⁺ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer. [PDF]

Nat Cell Biol
Wang L, Chu H, Chen D, Wei Y, Jia J, Li L, He L, Peng L, Liu F, Huang S, Jin Z, Zhou D, Fang W, Jiang T, Xu S, Ding X, Cai H, Liu X, Jia Q, Zhu B, Chu Q.   +20 more
europepmc   +1 more source

Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science, EarlyView.
Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
wiley   +1 more source

Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication. [PDF]

mBio
Liu Y, Kong N, Yang X, Qin W, Wang Y, Wang C, Sun H, Wang J, Gao A, Zheng D, Tong W, Yu H, Zheng H, Tong G, Shan T.   +14 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Regulatory T-cell sensing of extracellular ATP via P2RX7 promotes their accumulation and suppression and drives lung tumor growth. [PDF]

Cancer Immunol Res
Santiago-Carvalho I, Francisco R, de Gois Macedo B, Salgado CL, Stoll CR, Shao S, Beniwal A, Kwok T, Banuelos A, Cione MP, White E, Johnston TM, Leff CL, Silva-Junior I, Carvalho de Souza F, Thant W, Pandya P, D'Imperio Lima MR, Fernandez-Bussy S, Abia-Trujillo D, Vu LH, Tran NL, Husta BC, Copland JA, Gounari F, Justilien V, Lancaster JN, Borges da Silva H.   +27 more
europepmc   +1 more source