Results 41 to 50 of about 1,352,600 (310)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The rule of five should not impede anti-parasitic drug development

International Journal for Parasitology: Drugs and Drug Resistance, 2017
The “rule of 5” has become a mainstay of decision-making in the pharmaceutical industry as well as in nonindustrial (academic and institutional) drug development.
James H. McKerrow, Christopher A. Lipinski, Ph.D., LLC   +1 more
doaj   +1 more source

Accuracy of image-free navigation in intraoperative leg length change from total hip arthroplasty using evaluations from 2D and 3D measurements

BMC Musculoskeletal Disorders, 2021
Background Leg length discrepancy is one of the most common problems after total hip arthroplasty (THA). The aim of this study was to investigate the accuracy of image-free navigation in intraoperative leg length change (LLC) using evaluations from ...
Shine Tone, Masahiro Hasegawa, Yohei Naito, Hiroki Wakabayashi, Akihiro Sudo   +4 more
doaj   +1 more source

Beach Profile, Water Level, and Wave Runup Measurements Using a Standalone Line-Scanning, Low-Cost (LLC) LiDAR System

Remote Sensing, 2022
A prototype rapidly deployable, Line-scanning, Low-Cost (LLC) LiDAR system (USD 400 per unit; 2020) was developed to measure coastal hydro-morphodynamic processes. A pilot field study was conducted at the U.S.
Christopher S. O’Connor, Ryan S. Mieras   +1 more
doaj   +1 more source

City Wide Adhan as heard from near Masgid Sheikh Abdullah on 08-08-2010 at 1:02pm: Dhurh Adhan [PDF]

, 2010
Five times a day in the 83 square mile city of Cairo, over 30,000 muezzins call out the adhan, or call to prayer, calling believers to come and to pray.
Kipervaser, Anna, LLC, On Look Films
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

City Wide Adhan as heard from Al-Azhar Park on 01-26-2010 at 12:05pm: Dhurh Adhan [PDF]

, 2010
Five times a day in the 83 square mile city of Cairo, over 30,000 muezzins call out the adhan, or call to prayer, calling believers to come and to pray. This Dhurh (mid-day) adhan was recorded at Al-Azhar Park in the neighbourhood of Islamic Cairo.
Kipervaser, Anna, LLC, On Look Films
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Masgid Sultan Hassan: Sheikh Said: Adhan Recitation [PDF]

, 2010
Sheikh Said demonstrates the adhan on February 1, 2010 at the great Sultan Hassan Mosque in Sayeda Aisha. He has been a muezzin here for 8 years.Video & audio recordings of 6 muezzins reciting the adhan (Muslim call to prayer), with supporting ...
Kipervaser, Anna, LLC, On Look Films
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source