Results 51 to 60 of about 13,515,683 (358)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Remote Sensing, 2022 A prototype rapidly deployable, Line-scanning, Low-Cost (LLC) LiDAR system (USD 400 per unit; 2020) was developed to measure coastal hydro-morphodynamic processes. A pilot field study was conducted at the U.S.
Christopher S. O’Connor +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The rule of five should not impede anti-parasitic drug development
International Journal for Parasitology: Drugs and Drug Resistance, 2017 The “rule of 5” has become a mainstay of decision-making in the pharmaceutical industry as well as in nonindustrial (academic and institutional) drug development.
James H. McKerrow +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Static Human Behavior Classification Based on LLC and GIST Features [PDF]
Jisuanji gongcheng, 2018 Aiming at the problem of static image human behavior recognition,a method of merging Local-constrained Linear Coding(LLC) and global feature descriptors is proposed.This method makes intensive sampling of the image,and extracts the Scale-Invariant ...
WANG Ende,LIU Qiaoying,LI Yong
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Advanced Science, 2021 Li‐excess layered cathode (LLC) materials have a high theoretical specific capacity of 250 mAh g−1 induced by transition metal (cationic) and oxygen (anionic) redox activity.
Yongju Lee +6 more
doaj +1 more source
IEEE Access, 2020 This paper proposes a three-phase inverter combined with two LLC resonant tanks series resonant DC-DC boost converter with variable frequency control. The three-phase inverter side of the proposed circuit is connected to identical two-level LLC tanks to ...
Mohamed Salem +6 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source