Results 61 to 70 of about 2,089,832 (287)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Influence of the Sampling Area on the Chemical, Physical, and Mechanical Properties of Grewia bicolor(GB) Fiber for Potential Use in the Reinforcement of Tannin Matrix Composites

open access: yesJournal of Natural Fibers
The aim of this study is to chemically, physically, and mechanically characterize Grewia bicolor (GB) fibers harvested in the NGONG locality located in the North Cameroon region for potential use in the elaboration of tannin matrix composites. The fibers
MICHEL MBERE TAOGA   +8 more
doaj   +1 more source

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

open access: yesCells, 2014
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression
Alexander Dietrich   +2 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

The Impact of Novel Anticoagulants on the Upper Gastrointestinal Tract Mucosa

open access: yesMedicina, 2020
Background and objectives: Although treatment with novel oral non-vitamin K antagonist 3anticoagulants (NOACs) is associated with an overall decrease in hemorrhagic complications compared to warfarin, the incidence of gastrointestinal bleeding remains ...
Lubomir Mihalkanin, Branislav Stancak
doaj   +1 more source

The Return due to Diversification of Real Estate to the US Mixed-Asset Portfolio [PDF]

open access: yes
Booth and Fama (1992) observe that the compound return and so the terminal wealth of a portfolio is greater than the weighted average of the compound returns of the individual investments, a difference referred to as the return due to diversification ...
Stephen Lee
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Probabilistic Estimation of During-Fault Voltages of Unbalanced Active Distribution: Methods and Tools

open access: yesEnergies
In low-voltage (LV) distribution networks, system operating conditions are always unbalanced due to the unpredictability of the load demand in each phase, coupled with a potentially asymmetrical network structure due to different phase conductors’ sizes ...
Matteo Bartolomeo   +2 more
doaj   +1 more source

The space of non-degenerate closed curves in a Riemannian manifold [PDF]

open access: yes, 2012
Let LM be the semigroup of non-degenerate based loops with a fixed initial/final frame in a Riemannian manifold M of dimension at least three. We compare the topology of LM to that of the loop space Omega FTM on the bundle of frames in the tangent bundle
Mostovoy, Jacob, Sadykov, Rustam
core  

A Linear Logic Programming Language for Concurrent Programming over Graph Structures

open access: yes, 2014
We have designed a new logic programming language called LM (Linear Meld) for programming graph-based algorithms in a declarative fashion. Our language is based on linear logic, an expressive logical system where logical facts can be consumed. Because LM
Cruz, Flavio   +3 more
core   +2 more sources

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