Results 71 to 80 of about 5,356 (217)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

eLife, 2019
Histones are a principal constituent of chromatin in eukaryotes and fundamental to our understanding of eukaryotic gene regulation. In archaea, histones are widespread but not universal: several lineages have lost histone genes.
Antoine Hocher, Maria Rojec, Jacob B Swadling, Alexander Esin, Tobias Warnecke   +4 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

The impact of the compaction and mineralogical composition on the retention behaviour of Opalinus Clay [PDF]

E3S Web of Conferences, 2020
Llabjani Qazim, Ferrari Alessio, Laloui Lyesse   +2 more
doaj   +1 more source

Open Source LMS

International Journal of Advanced Corporate Learning (iJAC), 2015
Here’s the Top 5 Security and Open Source Questions You Should Ask Your LMS ...
openaire   +3 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Detection of senescence using machine learning algorithms based on nuclear features

Nature Communications
Cellular senescence is a stress response with broad pathophysiological implications. Senotherapies can induce senescence to treat cancer or eliminate senescent cells to ameliorate ageing and age-related pathologies.
Imanol Duran, Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, Laura Bousset, Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwalder, Dominic J. Withers, Santiago Vernia, Robert D. Goldin, Jesús Gil   +14 more
doaj   +1 more source

Non-destructive testing of tennis strings

Vietnam Journal of Mechanics, 2008
The paper aims to illustrate three advantages of infrared thermography as a non-destructive, non-contact and in real time technique (a) to detect the occurrence of intrinsic dissipation localisation, (b) to observe the progressive damage processes and ...
Luong Minh Phuong
doaj   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Adopting Multi-Material Wire DED-LB in Naval Industry: A Case Study in Stainless Steel and Nickel-Based Alloys

Engineering Proceedings
Multi-material Directed Energy Deposition (DED) Additive Manufacturing (AM) processes enable the integration of different material properties into a single structure, addressing the requirements of various applications and working environments.
Konstantinos Tzimanis, Nikolas Gavalas, Nikolas Porevopoulos, Panagiotis Stavropoulos   +3 more
doaj   +1 more source