Results 51 to 60 of about 5,356 (217)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Visualising the coupled mechanics of CO2 breakthrough [PDF]

E3S Web of Conferences, 2020
Stavropoulou Eleni, Laloui Lyesse
doaj   +1 more source

Diagnosis of faults using a new VMD-WMRA approach, optimized by a new criterion: Industrial application

Advances in Mechanical Engineering
This paper proposes a new criterion for selecting the optimum number of Intrinsic Mode Functions (IMFs) from vibration signals measured on rotating machines.
Ammar Mrabti, Nouredine Ouelaa, Ramdane Younes, Mohamed Cherif Djamaa, Zakarya Ouelaa   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Cyclic behavior and energy approach of the fatigue of shape memory alloys

Vietnam Journal of Mechanics, 2009
This paper presents an energy-based low-cycle fatigue criterion that can be used in analyzing and designing structures made from shape memory alloys (SMAs) subjected to cyclic loading.
Ziad Moumni, Wael Zaki, Habibou Maitournam   +2 more
doaj   +1 more source

Incremental LM-Cut

Proceedings of the International Conference on Automated Planning and Scheduling, 2013
In heuristic search and especially in optimal classical planning the computation of accurate heuristic values can take up the majority of runtime. In many cases, the heuristic computations for a search node and its successors are very similar, leading to significant duplication of effort.
Florian Pommerening, Malte Helmert
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Enhancing autophagy by redox regulation extends lifespan in Drosophila

Nature Communications
Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H2O2 in vivo, we established a redox-shifted model by manipulating levels of the H2O2-degrading enzyme catalase
Claudia Lennicke, Ivana Bjedov, Sebastian Grönke, Katja E. Menger, Andrew M. James, Jorge Iván Castillo-Quan, Lucie A. G. van Leeuwen, Andrea Foley, Marcela Buricova, Jennifer Adcott, Alex Montoya, Holger B. Kramer, Pavel V. Shliaha, Angela Logan, Filipe Cabreiro, Michael P. Murphy, Linda Partridge, Helena M. Cochemé   +17 more
doaj   +1 more source