Results 41 to 50 of about 232,568 (285)
Scientific ReportsWe tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c.
Chiara Prodani +12 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Вестник Майкопского государственного технологического университета, 2023 Augmented reality (AR) and virtual reality (VR) are immersive technologies that allow users to get acquainted with digital content both in physical and virtual space, expanding the possibilities of the educational environment.The relevance of the ...
Anna Alexandrovna Paskova
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Determinação da subsidência devida a cavernas no sal-gema
Geotecnia, 2000 A exploração de grandes cavernas de armazenagem tem sempre a ocorrência de subsidência como consequência a longo prazo. Embora estes deslocamentos superficiais raramente tenham consequências estruturais quando ocorrem em zonas não habitadas, podem dar ...
J.Eduardo Menezes, Duc Minh
doaj +1 more source
Uterine sarcoma – time is worth its weight in gold
Polish Journal of Pathology, 2023 Leiomyosarcoma is one of the most common types of soft tissue sarcoma in adults, and it can occur in almost any part of the body. Uterine leiomyosarcoma constitutes 1% of all gynaecological tumours.
Dominik Pruski +8 more
doaj +1 more source
, 2002 We study the stability of quantum states of macroscopic systems of finite volume V, against weak classical noises (WCNs), weak perturbations from environments (WPEs), and local measurements (LMs).
Akira Shimizu +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nature CommunicationsPBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis.
Andrew Dimond +13 more
doaj +1 more source
The PolyMAX Frequency-Domain Method: A New Standard for Modal Parameter Estimation?
Shock and Vibration, 2004 Recently, a new non-iterative frequency-domain parameter estimation method was proposed. It is based on a (weighted) least-squares approach and uses multiple-input-multiple-output frequency response functions as primary data.
Bart Peeters +3 more
doaj +1 more source