Results 31 to 40 of about 5,356 (217)

Modelling and optimization of machining parameters during hardened steel AISID3 turning using RSM, ANN and DFA techniques: Comparative study

Journal of Mechanical Engineering and Sciences, 2020
Nowadays, the relationships linking the cutting conditions to the different technological parameters are becoming a major industrial objective.  The present work deals with some machinability investigations involving surface roughness and cutting force ...
Bouzid Lakhdar, Yallese Mohamed Athmane, Belhadi Salim, A. Haddad   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Transfer of Going Concern in Italy: Who Pays the Trade Debts?

University of Bologna Law Review, 2018
Article  2560,  paragraph  2,  of  the  Italian  Civil  Code  sets  forth  a  specific regulation  of  the  trade  debts  in  the  context  of  the  transfer  of  a  going  concern.  Such provision of law seems apparently clear. However, case law and the
Gregorio Salatino
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes

Scientific Reports
We tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c.
Chiara Prodani, Elaine E. Irvine, Alessandro Sardini, Hannah J. Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J. Withers, Mark A. Ungless, Matthias Merkenschlager, Amanda G. Fisher   +12 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Determinação da subsidência devida a cavernas no sal-gema

Geotecnia, 2000
A exploração de grandes cavernas de armazenagem tem sempre a ocorrência de subsidência como consequência a longo prazo. Embora estes deslocamentos superficiais raramente tenham consequências estruturais quando ocorrem em zonas não habitadas, podem dar ...
J.Eduardo Menezes, Duc Minh
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites

Nature Communications
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis.
Andrew Dimond, Do Hyeon Gim, Elizabeth Ing-Simmons, Chad Whilding, Holger B. Kramer, Dounia Djeghloul, Alex Montoya, Bhavik Patel, Sherry Cheriyamkunnel, Karen E. Brown, Pavel V. Shliaha, Juan M. Vaquerizas, Matthias Merkenschlager, Amanda G. Fisher   +13 more
doaj   +1 more source