Results 31 to 40 of about 27,877 (267)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The Transfer of Going Concern in Italy: Who Pays the Trade Debts?

University of Bologna Law Review, 2018
Article  2560,  paragraph  2,  of  the  Italian  Civil  Code  sets  forth  a  specific regulation  of  the  trade  debts  in  the  context  of  the  transfer  of  a  going  concern.  Such provision of law seems apparently clear. However, case law and the
Gregorio Salatino
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes

Scientific Reports
We tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c.
Chiara Prodani, Elaine E. Irvine, Alessandro Sardini, Hannah J. Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J. Withers, Mark A. Ungless, Matthias Merkenschlager, Amanda G. Fisher   +12 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Determinação da subsidência devida a cavernas no sal-gema

Geotecnia, 2000
A exploração de grandes cavernas de armazenagem tem sempre a ocorrência de subsidência como consequência a longo prazo. Embora estes deslocamentos superficiais raramente tenham consequências estruturais quando ocorrem em zonas não habitadas, podem dar ...
J.Eduardo Menezes, Duc Minh
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites

Nature Communications
PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated phosphorylation to dissociate from chromosomes in mitosis.
Andrew Dimond, Do Hyeon Gim, Elizabeth Ing-Simmons, Chad Whilding, Holger B. Kramer, Dounia Djeghloul, Alex Montoya, Bhavik Patel, Sherry Cheriyamkunnel, Karen E. Brown, Pavel V. Shliaha, Juan M. Vaquerizas, Matthias Merkenschlager, Amanda G. Fisher   +13 more
doaj   +1 more source

The PolyMAX Frequency-Domain Method: A New Standard for Modal Parameter Estimation?

Shock and Vibration, 2004
Recently, a new non-iterative frequency-domain parameter estimation method was proposed. It is based on a (weighted) least-squares approach and uses multiple-input-multiple-output frequency response functions as primary data.
Bart Peeters, Herman Van der Auweraer, Patrick Guillaume, Jan Leuridan   +3 more
doaj   +1 more source