Results 241 to 250 of about 117,740 (287)

Rapid Detection of <i>Philaenus italosignus</i> Drosopoulos & Remane, 2000 (Hemiptera: Aphrophoridae) with Real-Time PCR Probe LNA Technology. [PDF]

open access: yesInsects
Rizzo D   +13 more
europepmc   +1 more source

Locked nucleic acid-modified antisense oligonucleotides attenuate scar hyperplasia through targeted inhibition of CTGF. [PDF]

open access: yesFront Pharmacol
Li J   +10 more
europepmc   +1 more source

Correction: MiR-423-5p is a metabolic and growth tuner in hepatocellular carcinoma via MALAT-1 and mitochondrial interaction. [PDF]

open access: yesJ Exp Clin Cancer Res
Bocchetti M   +17 more
europepmc   +1 more source
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LNA and α-L-LNA: Towards Therapeutic Applications

Nucleosides, Nucleotides and Nucleic Acids, 2003
LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we report dose-dependent inhibition of HIV-1 Tat-dependent trans activation by a 12-mer chimeric alpha-L-LNA/DNA oligomer. This oligomer exhibits a dose-dependency similar to that of the corresponding 12-mer chimeric LNA/2'-O-Me-
Wengel, J.   +9 more
openaire   +4 more sources

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

Bioorganic & Medicinal Chemistry Letters, 1998
LNA (Locked Nucleic Acids, 1, X = O, Y = O) is a novel oligonucleotide analogue capable of recognizing complementary DNA and RNA with unprecedented thermal affinities. Synthesis of the first chemically modified LNA analogues is reported. A 9-mer phosphorothioate-LNA containing three LNA thymine monomers (1, X = O, Y = S, Base = thymin-1-yl) and 9-mer ...
Kumar, Ravindra   +5 more
openaire   +3 more sources

High-affinity nucleic acid recognition using ‘LNA’ (locked nucleic acid, β-D-ribo configured LNA), ‘xylo-LNA’ (β-D-xylo configured LNA) or ‘α-L-LNA’ (α-L-ribo configured LNA)

Chemical Communications, 1999
Remarkably strong binding affinities towards complementary single stranded DNA and RNA were obtained for 10- and 14-mer LNAs (locked nucleic acids) containing diastereoisomeric β-D-ribo, β-D-xylo or α-L-ribo configured LNA thymine monomers; a possible relevance of these results in relation to nucleic acid evolution is discussed.
Rajwanshi, Vivek Kumar   +3 more
openaire   +1 more source

Nuclease Stability of LNA Oligonucleotides and LNA‐DNA Chimeras

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Miriam, Frieden   +2 more
openaire   +2 more sources

UHF Wideband GaAs MMIC LNA

2021 IEEE 19th International Symposium on Antenna Technology and Applied Electromagnetics (ANTEM), 2021
A wideband room temperature UHF-band MMIC low noise amplifier based on 0.15 μm pHEMT GaAs technology is presented. The amplifier achieves about 30 dB gain over a five-octave frequency range from 300 MHz to 1.5 GHz with minimum noise of 0.55 dB at room temperature.
Seyfollahi, Alireza   +3 more
openaire   +2 more sources

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