Results 251 to 260 of about 117,740 (287)

Lna (Locked Nucleic Acid)

Nucleosides and Nucleotides, 1999
Abstract LNA (Locked Nucleic Acid) forms duplexes with complementary DNA, RNA or LNA with unprecedented thermal affinities. CD spectra show that duplexes involving fully modified LNA (especially LNA:RNA) structurally resemble an A-form RNA:RNA duplex. NMR examination of an LNA:DNA duplex confirm the 3′-endo conformation of an LNA monomer.
Wengel, J., Koshkin, A., Singh, S. K., Nielsen, P., Meldgaard, M., Rajwanshi Singh, V. K., Kumar, R., Skouv, J., Nielsen, C. B., Jacobsen, J. P., Jacobsen, N., Olsen, C. E.   +11 more
openaire   +2 more sources

STRUCTURAL STUDIES ON LNA QUADRUPLEXES

Nucleosides, Nucleotides & Nucleic Acids, 2005
LNAs (locked nucleic acids) are new DNA analogues with higher binding affinities toward nucleic acids than the canonical counterparts mainly due to the characteristic conformational restriction arising from the 2'-O, 4'-C methylene bridge. In light of the promising therapeutic applications and considering the advantageous characteristics of LNAs, such ...
RANDAZZO, ANTONIO, ESPOSITO, VERONICA, OLIVER OHLENSCHLÄGER, RAMADURAI RAMACHANDRAN, VIRGILIO, ANTONELLA, MAYOL, LUCIANO   +5 more
openaire   +3 more sources

Structural Characterization of LNA and α-L-LNA Hybridized to RNA

Nucleosides, Nucleotides and Nucleic Acids, 2003
LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we present a short overview of the structural results we have obtained for LNA:RNA and alpha-L-LNA:RNA hybrids. Specifically, we have shown that LNA acts as an A-type mimic, while alpha-L-LNA acts as a B-type mimic when built ...
Petersen, M., Nielsen, J.T., Bondensgaard, K., Wengel, J., Jacobsen, J.P.   +4 more
openaire   +3 more sources

LNA characterization methodologies

International Journal of Circuit Theory and Applications, 2016
SummaryJoint characterization of low‐noise amplifiers regarding stochastic and deterministic parameters based on output power measurement for a set of known input termination impedances is considered. As an advantage of this method, both noise parameters and the input impedance can be obtained for narrow and broad band applications without special ...
Bernhard Lehmeyer, Michel T. Ivrlač, Josef A. Nossek   +2 more
openaire   +1 more source

SiGe LNAs for UMTS System

Analog Integrated Circuits and Signal Processing, 2001
Three LNAs at 2 GHz frequency range have been implemented in a SiGe Bipolar process targeted for a universal mobile telecommunications system. The LNAs are operating in two gain modes and they include a power-down mode. Both on-wafer and packaged LNAs were measured.
Ryynänen Jussi, Stadius Kari, Halonen Kari   +2 more
openaire   +1 more source

New Standards in LNA Synthesis

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Henrik F, Hansen, Otto, Olsen, Troels, Koch   +2 more
openaire   +2 more sources

Improved Synthesis of 2′‐Amino‐LNA

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Christensen, S.M., Rosenbohm, C., Sørensen, M.., Larsen, L.-E., Wengel, J., Koch, T.   +5 more
openaire   +3 more sources

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions

Bioorganic & Medicinal Chemistry Letters, 2014
Forty modified versions of a streptavidin-binding aptamer each containing single or multiple LNA or α-l-LNA-substitutions were synthesized and their dissociation constants determined by surface plasmon resonance experiments. Both full-length and truncated versions of the aptamer were studied and compared with the unmodified DNA aptamers.
Jørgensen, Anna S.; Hansen, Lykke H.; Vester, Birte; Wengel, Jesper   +4 more
openaire   +3 more sources

Structural Characterization of LNA and α‐L‐LNA Hybridized to RNA

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael Petersen, Jakob T. Nielsen, Kent Bondensgaard, Jesper Wengel, Jens Peter Jacobsen   +4 more
openaire   +1 more source

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex

Chemical Communications, 2006
We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero ...
Sherri, Rinker, Yan, Liu, Hao, Yan
openaire   +2 more sources