Results 181 to 190 of about 1,670,871 (318)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Effect of hybrid fibre reinforcement and rubber aggregates on the flexural performance of reinforced concrete beams. [PDF]

Sci Rep
Karthikeyan R, Anuradha B, Deepa K.
europepmc   +1 more source

Superior fracture resistance of additive manufactured high-entropy alloy under impact loading

Yixin Lin, Yang Yin, Weijia Zheng, Zhiyong Gao, Xiaohong Chen, Lian X. Liu, Jie Pan   +6 more
openalex   +1 more source

Study of the Dynamic Loading Impact on the Design of Pentices when Sinking Vertical Mine Shafts [PDF]

, 2018
Vladimir Pershin, А.I. Кopytov, Fadeev Yuriy, Ahmed Wetti   +3 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Inspiratory muscle training in the healthy adult: The relationship between load, perception, and oxygen consumption. [PDF]

Clin Physiol Funct Imaging
Jenkins TO, Karbing DS, Rees SE, Scott W, Aristidou C, Poulsen MK, Polkey MI, MacBean V.   +7 more
europepmc   +1 more source

Effect of cyclic loads on structural damage of rocket propellant grain [PDF]

, 2019
Nikola Gligorijević, Vesna Rodić, Bojan Pavković, Jovica Bogdanov, Saša Živković, Zoran Bajić   +5 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaluation of the Seismic Behavior of Carbon-Grid-Reinforced Walls with Varying Anchorage and Axial Load Ratios. [PDF]

Polymers (Basel)
Kim KM, Park SW, Song BK, Min KJ, Yoon SH.   +4 more
europepmc   +1 more source

Work Mental Load Analysis on Car Repair Mechanics in Yogyakarta

, 2020
Atyanti Dyah Prabaswari, Bagus Wahyu Utomo   +1 more
openalex   +1 more source