Results 41 to 50 of about 83,057 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Analysis of a rapid load test on an instrumented bored pile in clay [PDF]

, 2006
Rapid load testing methods for piled foundations are generally easier and quicker to mobilise than classic static tests, and are less complex to analyse than dynamic load tests.
Brown, M. J.; id_orcid, Anderson, W. F., Hyde, A. F. L.   +2 more
core   +1 more source

Experimental Investigation on Web Crippling Property of High-Strength Cold-Formed (HSCF) Rectangular Steel Tube

Advances in Civil Engineering, 2020
To research the web crippling performance (i.e., the ultimate web crippling bearing capacity and ductility) of high-strength cold-formed (HSCF) rectangular steel tubes under concentrated load, thirty-six specimens with different bearing plate width ...
Xianglong Liu, Jicheng Zhang, Yuanqi Li, Lei Zeng, Guofeng Du   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Simulation analysis of energy absorption characteristics of hyperbolic shallow shell anti-impact energy absorbing components

Meikuang Anquan
To enhance the impact resistance and energy absorption performance of hydraulic supports in mitigating coal mine rock burst, a hyperbolic shallow shell anti-impact energy-absorbing component was designed.
Dong AN, Jiawei TU, Hailiang XU, Zhiyang WANG, Runsong TANG   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bearing capacity of cold-formed unlipped channels with restrained flanges under EOF and IOF load cases

, 2015
Bearing failure is a form of localized failure that occurs when thin-walled cold-formed steel sections are subjected to concentrated loads or support reactions.
Mahendran, Mahen, Janarthanan, Balasubramaniam, Gunalan, Shanmuganathan   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Ultimate Load-bearing Capacity of Self-anchored Suspension Bridges

, 2011
This paper presents a method of reduced stiffness coupled with step increments to simulate the nonlinear problem that occurs when a material is in the elasto-plastic stage.
Kao, Chin-Sheng, Kao, Chin-Sheng; Kou, Chang-Huan; Qiu, Wen-Liang; Tsai, Jeng-Lin   +1 more
core   +1 more source