Results 51 to 60 of about 83,057 (306)

Study on Load-Bearing Characteristics and Engineering Applications for Cement–Soil Pipe Pile

Buildings
The cement–soil pipe pile is a novel blend of cement and soil, designed to enhance load-bearing capabilities while cutting down on the need for cement. Its tubular construction is key to its strength.
Chong Zhou, Xiangzhuo Zheng, Sifeng Zhang, Chao Li, Yaohui Yang, Jianyong Han   +5 more
doaj   +1 more source

Theoretical Analysis for Stability Evaluation of Rock Mass Engineering Structure under Combined Compression-Shear Loading: A Case Study of Inclined Pillar

Applied Sciences, 2021
An inclined pillar is a typical support structure under compression and shear loads for underground mining. The shear load caused by the inclination of the ore-body affects the bearing capacity of the pillar.
Lijun Sun, Yicheng Ye, Binyu Luo, Nanyan Hu, Pengcheng Li   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evolution Mechanism and Cyclic Degradation Model of Ultimate Bearing Capacity for Suction Caissons Under Inclined Combined Loading

Applied Sciences
In the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang, Bingzhen Yu, Bo Liu, Liji Huang, Huiyuan Deng, Wenbo Zhu, Guoliang Dai   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Advanced Bearing System for Ultra Precision Plastic Electronics Production Systems [PDF]

, 2014
The aims of this MSc research project are to investigate the application of aluminium for the main components of an ultra-precision spindle defined for use in R2R production systems and to produce a reel to reel rotary aluminium hydrostatic bearing ...
Zhao, Gang
core  

Load-bearing capacity and critical water content of the coffee plantation soil with management in full sun and shaded

, 2022
New management practices applied to coffee crops may influence the soil’s capacity to tolerate vertical stresses. This paper aimed to evaluate the influence of two coffee crop management systems on the soil load-bearing capacity and critical soil water ...
Kátia Daniela Ribeiro (13778761), Kasé Santos Lacerda (13778752), Kleber Mariano Ribeiro (13778758), Dorotéo de Abreu (13778764), Moacir de Souza Dias Junior (8368842), Rafaela Carvalho Vargas (13778755)   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

载荷和几何参数对单排四点接触球轴承载荷分布的影响

Jixie chuandong, 2013
The load distribution analysis is the foundation of carrying load capacity analysis, the drawing of static carrying load capacity curve, designing and selecting of slewing bearing.
张黎燕, 王燕霜, 袁倩倩, 籍永刚   +3 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source