Results 101 to 110 of about 512,767 (268)

Calculation Method and Experimental Investigation of Root Bending Stress in Line Contact Spiral Bevel Gear Pairs

Machines
Compared to spiral bevel gear drives with localized conjugation, line contact spiral bevel gears possess a significantly larger meshing area, theoretically achieving full tooth surface contact and substantially enhancing load capacity.
Shiyu Zuo, Yuehai Sun, Liang Chen, Simin Li, Mingyang Wang   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Changes in human calcaneal morphology throughout the Pleistocene-Holocene Levant

Frontiers in Earth Science
The calcaneal morphology changed considerably during human evolution to enable efficient bipedal locomotion. However, little information exists regarding its adaptation to changes in habitual activities following the transition to a sedentary lifestyle ...
Ariana Dann, Ariana Dann, Ariel Pokhojaev, Ariel Pokhojaev, Ariel Pokhojaev, Marie Anton, Guy Yalovitsky, Guy Yalovitsky, Ruth Kallevag-Pelleg, Ruth Kallevag-Pelleg, Ruth Kallevag-Pelleg, Hila May, Hila May   +12 more
doaj   +1 more source

Cerebral amyloid angiopathy and amyloid load distribution detected on amyloid-positron emission tomography: A systematic review and meta-analysis. [PDF]

Eur Stroke J
Theodorou A, Melanis K, Athanasaki A, Palaiodimou L, Stefanou MI, Tsalouchidou PE, Vassilopoulos E, Kouzoupis A, Themistocleous M, Paraskevas GP, Tzavellas E.   +10 more
europepmc   +2 more sources

Consideration of load distribution and native soft tissue anatomy when choosing an animal bony model. [PDF]

Ann Transl Med, 2023
Anastasio AT, Grant C, Peairs EM, Fernandez-Moure JS.   +3 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Load distribution after unilateral condylar fracture with shortening of the ramus: a finite element model study. [PDF]

Head Face Med, 2023
Helmer LML, Klop C, Lobbezoo F, de Lange J, Koolstra JH, Dubois L.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prospective analysis of grip strength and load distribution after surgical treatment of common diseases of the hand with novel's manugraphy^® system. [PDF]

Arch Orthop Trauma Surg, 2023
Grüner JS, Cai A, Pingel I, Horch RE, Beier JP, Arkudas A.   +5 more
europepmc   +1 more source