Results 131 to 140 of about 18,979,128 (346)

Parameter analysis of copper-nickel-tungsten prepared via powder metallurgy process for electrical discharge machining of polycrystalline diamond [PDF]

open access: yes, 2019
Polycrystalline Diamond (PCD) tools have an outstanding wear resistance. The electric conductivity of PCD caused by the conductive binding material (Cobalt) makes it possible to machine PCD tools with EDM.
Sabri, Ainaa Mardhiah
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Studi Demand Kereta Api Komuter Lawang - Kepanjen

open access: yesJurnal Teknik ITS, 2013
Dengan semakin pesatnya perkembangan perekonomian di propinsi Jawa Timur, khususnya di area Malang Raya mengakibatkan tingginya perpindahan orang maupun barang di area tersebut.
Rendy Prasetya Rachman, Wahju Herijanto
doaj  

Random vibration analysis of space flight hardware using NASTRAN [PDF]

open access: yes
During liftoff and ascent flight phases, the Space Transportation System (STS) and payloads are exposed to the random acoustic environment produced by engine exhaust plumes and aerodynamic disturbances.
Thampi, S. K., Vidyasagar, S. N.
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

THE CONCEPT OF ORGANIZING TRANSPORT AND LOGISTICS PROCESSES, TAKING INTO ACCOUNT THE ECONOMIC, SOCIAL AND ENVIRONMENTAL ASPECTS [PDF]

open access: yesTransport Problems, 2015
Current model of organization of supply chains results in inefficient use of transport resources, high transport costs, increasing congestions and CO2 emission.
Leszek MINDUR, Marcin HAJDUL
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The Comparative Efficiency of Public and Private Power Plants in Pakistan’s Electricity Industry

open access: yesLahore Journal of Economics
This study estimates a cost function for fossil fuel-based electricity generating plants operating in Pakistan during 2006–11. It employs a six-year panel dataset for 31 plants to estimate the cost function parameters.
Amir Jahan Khan
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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