Results 161 to 170 of about 5,818,378 (300)

Parametric Design and Finite Element-Based Structural Assessment of Industrial Moulds for Concrete Blocks. [PDF]

Materials (Basel)
Tatayo-Tipantasi E, Erazo-Arteaga V, Tafur-Escanta P, Tafur JP, Valencia-Chapi R.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Framework for Analyzing the Effects of Spring Load Restriction [PDF]

Spring Load Restrictions (SLR) impose load restrictions on heavy trucks during the spring thaw period. Although the policies have been implemented for many years, we are still unsure of their economic effects on truckers.
Xi Zou, Ning Li, Brian Smalkoski, David Levinson, Maryam Hashami   +4 more
core  

Rapid Estimation Method for Gear Bending Fatigue Limit. [PDF]

Materials (Basel)
Yang C, Zhao X, Yu X, Li Z, Li W.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

INFLUENCING LOAD FACTOR IN TRANSPORT OPERATIONS: A LITERATURE REVIEW

, 2014
Purpose: One key variable for improving efficiency in freight transport systems is to increase the load factor; the ratio of the actual load carried to the maximum load that could have been carried.
Rogerson, Sara, Sant\ue9n, Vendela, Santén, Vendela   +2 more
core  

Crack initiation and propagation at crack tips of prefabricated flawed sandstone under uniaxial compression. [PDF]

Sci Rep
Jiang C, Zhang X, Wang Y, Hei Q, Ma H, Huai H.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Optimization of Microwave-Assisted Fracture Energy Recovery in Early-Damaged Asphalt Mixtures: Damage-State Regulation by Basalt Fiber Reinforcement. [PDF]

Materials (Basel)
Li B, Hu J, Wang Y, Kang A, Wu Z.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source